Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?

The majority of people infected with SARS-CoV-2 are asymptomatic or have mild to moderate symptoms. However, for unknown reasons, about 15 % have severe pneumonia requiring hospital care and oxygen support, and about 5 % develop acute respiratory distress syndrome, septic shock, and multiorgan failu...

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Autor principal: Söderberg-Nauclér, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952506/
https://www.ncbi.nlm.nih.gov/pubmed/33712035
http://dx.doi.org/10.1186/s12979-021-00218-z
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author Söderberg-Nauclér, Cecilia
author_facet Söderberg-Nauclér, Cecilia
author_sort Söderberg-Nauclér, Cecilia
collection PubMed
description The majority of people infected with SARS-CoV-2 are asymptomatic or have mild to moderate symptoms. However, for unknown reasons, about 15 % have severe pneumonia requiring hospital care and oxygen support, and about 5 % develop acute respiratory distress syndrome, septic shock, and multiorgan failure that result in a high mortality rate. The risk of severe COVID-19 is highest among those who are over 70 years of age. Why severe COVID-19 develops in some people but not others is not understood. Could some cases involve reactivation of latent cytomegalovirus (CMV)?
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spelling pubmed-79525062021-03-12 Does reactivation of cytomegalovirus contribute to severe COVID-19 disease? Söderberg-Nauclér, Cecilia Immun Ageing Commentary The majority of people infected with SARS-CoV-2 are asymptomatic or have mild to moderate symptoms. However, for unknown reasons, about 15 % have severe pneumonia requiring hospital care and oxygen support, and about 5 % develop acute respiratory distress syndrome, septic shock, and multiorgan failure that result in a high mortality rate. The risk of severe COVID-19 is highest among those who are over 70 years of age. Why severe COVID-19 develops in some people but not others is not understood. Could some cases involve reactivation of latent cytomegalovirus (CMV)? BioMed Central 2021-03-12 /pmc/articles/PMC7952506/ /pubmed/33712035 http://dx.doi.org/10.1186/s12979-021-00218-z Text en © The Author(s) 2021 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Commentary
Söderberg-Nauclér, Cecilia
Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?
title Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?
title_full Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?
title_fullStr Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?
title_full_unstemmed Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?
title_short Does reactivation of cytomegalovirus contribute to severe COVID-19 disease?
title_sort does reactivation of cytomegalovirus contribute to severe covid-19 disease?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952506/
https://www.ncbi.nlm.nih.gov/pubmed/33712035
http://dx.doi.org/10.1186/s12979-021-00218-z
work_keys_str_mv AT soderbergnauclercecilia doesreactivationofcytomegaloviruscontributetoseverecovid19disease

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