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Protein Trafficking or Cell Signaling: A Dilemma for the Adaptor Protein TOM1

Lysosomal degradation of ubiquitinated transmembrane protein receptors (cargo) relies on the function of Endosomal Sorting Complex Required for Transport (ESCRT) protein complexes. The ESCRT machinery is comprised of five unique oligomeric complexes with distinct functions. Target of Myb1 (TOM1) is...

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Autores principales: Roach, Tiffany G., Lång, Heljä K. M., Xiong, Wen, Ryhänen, Samppa J., Capelluto, Daniel G. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952518/
https://www.ncbi.nlm.nih.gov/pubmed/33718385
http://dx.doi.org/10.3389/fcell.2021.643769
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author Roach, Tiffany G.
Lång, Heljä K. M.
Xiong, Wen
Ryhänen, Samppa J.
Capelluto, Daniel G. S.
author_facet Roach, Tiffany G.
Lång, Heljä K. M.
Xiong, Wen
Ryhänen, Samppa J.
Capelluto, Daniel G. S.
author_sort Roach, Tiffany G.
collection PubMed
description Lysosomal degradation of ubiquitinated transmembrane protein receptors (cargo) relies on the function of Endosomal Sorting Complex Required for Transport (ESCRT) protein complexes. The ESCRT machinery is comprised of five unique oligomeric complexes with distinct functions. Target of Myb1 (TOM1) is an ESCRT protein involved in the initial steps of endosomal cargo sorting. To exert its function, TOM1 associates with ubiquitin moieties on the cargo via its VHS and GAT domains. Several ESCRT proteins, including TOLLIP, Endofin, and Hrs, have been reported to form a complex with TOM1 at early endosomal membrane surfaces, which may potentiate the role of TOM1 in cargo sorting. More recently, it was found that TOM1 is involved in other physiological processes, including autophagy, immune responses, and neuroinflammation, which crosstalk with its endosomal cargo sorting function. Alteration of TOM1 function has emerged as a phosphoinositide-dependent survival mechanism for bacterial infections and cancer progression. Based on current knowledge of TOM1-dependent cellular processes, this review illustrates how TOM1 functions in coordination with an array of protein partners under physiological and pathological scenarios.
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spelling pubmed-79525182021-03-13 Protein Trafficking or Cell Signaling: A Dilemma for the Adaptor Protein TOM1 Roach, Tiffany G. Lång, Heljä K. M. Xiong, Wen Ryhänen, Samppa J. Capelluto, Daniel G. S. Front Cell Dev Biol Cell and Developmental Biology Lysosomal degradation of ubiquitinated transmembrane protein receptors (cargo) relies on the function of Endosomal Sorting Complex Required for Transport (ESCRT) protein complexes. The ESCRT machinery is comprised of five unique oligomeric complexes with distinct functions. Target of Myb1 (TOM1) is an ESCRT protein involved in the initial steps of endosomal cargo sorting. To exert its function, TOM1 associates with ubiquitin moieties on the cargo via its VHS and GAT domains. Several ESCRT proteins, including TOLLIP, Endofin, and Hrs, have been reported to form a complex with TOM1 at early endosomal membrane surfaces, which may potentiate the role of TOM1 in cargo sorting. More recently, it was found that TOM1 is involved in other physiological processes, including autophagy, immune responses, and neuroinflammation, which crosstalk with its endosomal cargo sorting function. Alteration of TOM1 function has emerged as a phosphoinositide-dependent survival mechanism for bacterial infections and cancer progression. Based on current knowledge of TOM1-dependent cellular processes, this review illustrates how TOM1 functions in coordination with an array of protein partners under physiological and pathological scenarios. Frontiers Media S.A. 2021-02-26 /pmc/articles/PMC7952518/ /pubmed/33718385 http://dx.doi.org/10.3389/fcell.2021.643769 Text en Copyright © 2021 Roach, Lång, Xiong, Ryhänen and Capelluto. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Roach, Tiffany G.
Lång, Heljä K. M.
Xiong, Wen
Ryhänen, Samppa J.
Capelluto, Daniel G. S.
Protein Trafficking or Cell Signaling: A Dilemma for the Adaptor Protein TOM1
title Protein Trafficking or Cell Signaling: A Dilemma for the Adaptor Protein TOM1
title_full Protein Trafficking or Cell Signaling: A Dilemma for the Adaptor Protein TOM1
title_fullStr Protein Trafficking or Cell Signaling: A Dilemma for the Adaptor Protein TOM1
title_full_unstemmed Protein Trafficking or Cell Signaling: A Dilemma for the Adaptor Protein TOM1
title_short Protein Trafficking or Cell Signaling: A Dilemma for the Adaptor Protein TOM1
title_sort protein trafficking or cell signaling: a dilemma for the adaptor protein tom1
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952518/
https://www.ncbi.nlm.nih.gov/pubmed/33718385
http://dx.doi.org/10.3389/fcell.2021.643769
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