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Alterations in Gut Microbial Communities Across Anatomical Locations in Inflammatory Bowel Diseases

We previously discovered that gut microbiota can serve as universal microbial biomarkers for diagnosis, disease activity assessment, and predicting the response to infliximab treatment for inflammatory bowel diseases (IBD). Much still remains unknown about the relationship between alterations in gut...

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Autores principales: Zhou, Youlian, He, Yan, Liu, Le, Zhou, Wanyan, Wang, Pu, Hu, Han, Nie, Yuqiang, Chen, Ye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952524/
https://www.ncbi.nlm.nih.gov/pubmed/33718417
http://dx.doi.org/10.3389/fnut.2021.615064
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author Zhou, Youlian
He, Yan
Liu, Le
Zhou, Wanyan
Wang, Pu
Hu, Han
Nie, Yuqiang
Chen, Ye
author_facet Zhou, Youlian
He, Yan
Liu, Le
Zhou, Wanyan
Wang, Pu
Hu, Han
Nie, Yuqiang
Chen, Ye
author_sort Zhou, Youlian
collection PubMed
description We previously discovered that gut microbiota can serve as universal microbial biomarkers for diagnosis, disease activity assessment, and predicting the response to infliximab treatment for inflammatory bowel diseases (IBD). Much still remains unknown about the relationship between alterations in gut microbiota and IBD affected bowel region, in particular in the case of ulcerative colitis (UC) and colonic Crohn's disease (cCD) without endoscopic and biopsy data. In the current study gut microbiota from a population in China was found to be distinct from that of the Western world [Human Microbiome Project (HMP) data]. Furthermore, both gut microbiota greatly differed from microbiota of other anatomical locations (oral, skin, airway, and vagina), with higher alpha-diversity (Chinese gut > HMP gut > oral microbiome > airway microbiome > skin microbiome > vaginal microbiome), and marked differences in microbiome composition. In patients with IBD in China, UC was characterized by the presence of Gardnerella, while cCD was characterized by the presence of Fusobacterium. Moreover, gut microbiota, such as Gardnerella and Fusobacterium, may be potential biomarkers for identifying UC from cCD. Together, this study revealed crucial differences in microbial communities across anatomical locations, and demonstrated that there was an important association between IBD affected bowel region and gut microbiota.
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spelling pubmed-79525242021-03-13 Alterations in Gut Microbial Communities Across Anatomical Locations in Inflammatory Bowel Diseases Zhou, Youlian He, Yan Liu, Le Zhou, Wanyan Wang, Pu Hu, Han Nie, Yuqiang Chen, Ye Front Nutr Nutrition We previously discovered that gut microbiota can serve as universal microbial biomarkers for diagnosis, disease activity assessment, and predicting the response to infliximab treatment for inflammatory bowel diseases (IBD). Much still remains unknown about the relationship between alterations in gut microbiota and IBD affected bowel region, in particular in the case of ulcerative colitis (UC) and colonic Crohn's disease (cCD) without endoscopic and biopsy data. In the current study gut microbiota from a population in China was found to be distinct from that of the Western world [Human Microbiome Project (HMP) data]. Furthermore, both gut microbiota greatly differed from microbiota of other anatomical locations (oral, skin, airway, and vagina), with higher alpha-diversity (Chinese gut > HMP gut > oral microbiome > airway microbiome > skin microbiome > vaginal microbiome), and marked differences in microbiome composition. In patients with IBD in China, UC was characterized by the presence of Gardnerella, while cCD was characterized by the presence of Fusobacterium. Moreover, gut microbiota, such as Gardnerella and Fusobacterium, may be potential biomarkers for identifying UC from cCD. Together, this study revealed crucial differences in microbial communities across anatomical locations, and demonstrated that there was an important association between IBD affected bowel region and gut microbiota. Frontiers Media S.A. 2021-02-26 /pmc/articles/PMC7952524/ /pubmed/33718417 http://dx.doi.org/10.3389/fnut.2021.615064 Text en Copyright © 2021 Zhou, He, Liu, Zhou, Wang, Hu, Nie and Chen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Zhou, Youlian
He, Yan
Liu, Le
Zhou, Wanyan
Wang, Pu
Hu, Han
Nie, Yuqiang
Chen, Ye
Alterations in Gut Microbial Communities Across Anatomical Locations in Inflammatory Bowel Diseases
title Alterations in Gut Microbial Communities Across Anatomical Locations in Inflammatory Bowel Diseases
title_full Alterations in Gut Microbial Communities Across Anatomical Locations in Inflammatory Bowel Diseases
title_fullStr Alterations in Gut Microbial Communities Across Anatomical Locations in Inflammatory Bowel Diseases
title_full_unstemmed Alterations in Gut Microbial Communities Across Anatomical Locations in Inflammatory Bowel Diseases
title_short Alterations in Gut Microbial Communities Across Anatomical Locations in Inflammatory Bowel Diseases
title_sort alterations in gut microbial communities across anatomical locations in inflammatory bowel diseases
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952524/
https://www.ncbi.nlm.nih.gov/pubmed/33718417
http://dx.doi.org/10.3389/fnut.2021.615064
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