Metabolomics of sebum reveals lipid dysregulation in Parkinson’s disease

Parkinson’s disease (PD) is a progressive neurodegenerative disorder, which is characterised by degeneration of distinct neuronal populations, including dopaminergic neurons of the substantia nigra. Here, we use a metabolomics profiling approach to identify changes to lipids in PD observed in sebum,...

Descripción completa

Detalles Bibliográficos
Autores principales: Sinclair, Eleanor, Trivedi, Drupad K., Sarkar, Depanjan, Walton-Doyle, Caitlin, Milne, Joy, Kunath, Tilo, Rijs, Anouk M., de Bie, Rob M. A., Goodacre, Royston, Silverdale, Monty, Barran, Perdita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952564/
https://www.ncbi.nlm.nih.gov/pubmed/33707447
http://dx.doi.org/10.1038/s41467-021-21669-4
_version_ 1783663754543628288
author Sinclair, Eleanor
Trivedi, Drupad K.
Sarkar, Depanjan
Walton-Doyle, Caitlin
Milne, Joy
Kunath, Tilo
Rijs, Anouk M.
de Bie, Rob M. A.
Goodacre, Royston
Silverdale, Monty
Barran, Perdita
author_facet Sinclair, Eleanor
Trivedi, Drupad K.
Sarkar, Depanjan
Walton-Doyle, Caitlin
Milne, Joy
Kunath, Tilo
Rijs, Anouk M.
de Bie, Rob M. A.
Goodacre, Royston
Silverdale, Monty
Barran, Perdita
author_sort Sinclair, Eleanor
collection PubMed
description Parkinson’s disease (PD) is a progressive neurodegenerative disorder, which is characterised by degeneration of distinct neuronal populations, including dopaminergic neurons of the substantia nigra. Here, we use a metabolomics profiling approach to identify changes to lipids in PD observed in sebum, a non-invasively available biofluid. We used liquid chromatography-mass spectrometry (LC-MS) to analyse 274 samples from participants (80 drug naïve PD, 138 medicated PD and 56 well matched control subjects) and detected metabolites that could predict PD phenotype. Pathway enrichment analysis shows alterations in lipid metabolism related to the carnitine shuttle, sphingolipid metabolism, arachidonic acid metabolism and fatty acid biosynthesis. This study shows sebum can be used to identify potential biomarkers for PD.
format Online
Article
Text
id pubmed-7952564
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-79525642021-03-28 Metabolomics of sebum reveals lipid dysregulation in Parkinson’s disease Sinclair, Eleanor Trivedi, Drupad K. Sarkar, Depanjan Walton-Doyle, Caitlin Milne, Joy Kunath, Tilo Rijs, Anouk M. de Bie, Rob M. A. Goodacre, Royston Silverdale, Monty Barran, Perdita Nat Commun Article Parkinson’s disease (PD) is a progressive neurodegenerative disorder, which is characterised by degeneration of distinct neuronal populations, including dopaminergic neurons of the substantia nigra. Here, we use a metabolomics profiling approach to identify changes to lipids in PD observed in sebum, a non-invasively available biofluid. We used liquid chromatography-mass spectrometry (LC-MS) to analyse 274 samples from participants (80 drug naïve PD, 138 medicated PD and 56 well matched control subjects) and detected metabolites that could predict PD phenotype. Pathway enrichment analysis shows alterations in lipid metabolism related to the carnitine shuttle, sphingolipid metabolism, arachidonic acid metabolism and fatty acid biosynthesis. This study shows sebum can be used to identify potential biomarkers for PD. Nature Publishing Group UK 2021-03-11 /pmc/articles/PMC7952564/ /pubmed/33707447 http://dx.doi.org/10.1038/s41467-021-21669-4 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Sinclair, Eleanor
Trivedi, Drupad K.
Sarkar, Depanjan
Walton-Doyle, Caitlin
Milne, Joy
Kunath, Tilo
Rijs, Anouk M.
de Bie, Rob M. A.
Goodacre, Royston
Silverdale, Monty
Barran, Perdita
Metabolomics of sebum reveals lipid dysregulation in Parkinson’s disease
title Metabolomics of sebum reveals lipid dysregulation in Parkinson’s disease
title_full Metabolomics of sebum reveals lipid dysregulation in Parkinson’s disease
title_fullStr Metabolomics of sebum reveals lipid dysregulation in Parkinson’s disease
title_full_unstemmed Metabolomics of sebum reveals lipid dysregulation in Parkinson’s disease
title_short Metabolomics of sebum reveals lipid dysregulation in Parkinson’s disease
title_sort metabolomics of sebum reveals lipid dysregulation in parkinson’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952564/
https://www.ncbi.nlm.nih.gov/pubmed/33707447
http://dx.doi.org/10.1038/s41467-021-21669-4
work_keys_str_mv AT sinclaireleanor metabolomicsofsebumrevealslipiddysregulationinparkinsonsdisease
AT trivedidrupadk metabolomicsofsebumrevealslipiddysregulationinparkinsonsdisease
AT sarkardepanjan metabolomicsofsebumrevealslipiddysregulationinparkinsonsdisease
AT waltondoylecaitlin metabolomicsofsebumrevealslipiddysregulationinparkinsonsdisease
AT milnejoy metabolomicsofsebumrevealslipiddysregulationinparkinsonsdisease
AT kunathtilo metabolomicsofsebumrevealslipiddysregulationinparkinsonsdisease
AT rijsanoukm metabolomicsofsebumrevealslipiddysregulationinparkinsonsdisease
AT debierobma metabolomicsofsebumrevealslipiddysregulationinparkinsonsdisease
AT goodacreroyston metabolomicsofsebumrevealslipiddysregulationinparkinsonsdisease
AT silverdalemonty metabolomicsofsebumrevealslipiddysregulationinparkinsonsdisease
AT barranperdita metabolomicsofsebumrevealslipiddysregulationinparkinsonsdisease

Ejemplares similares