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Joint analysis of expression levels and histological images identifies genes associated with tissue morphology

Histopathological images are used to characterize complex phenotypes such as tumor stage. Our goal is to associate features of stained tissue images with high-dimensional genomic markers. We use convolutional autoencoders and sparse canonical correlation analysis (CCA) on paired histological images...

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Detalles Bibliográficos
Autores principales:	Ash, Jordan T., Darnell, Gregory, Munro, Daniel, Engelhardt, Barbara E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952575/ https://www.ncbi.nlm.nih.gov/pubmed/33707455 http://dx.doi.org/10.1038/s41467-021-21727-x

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