Systemic deletion of Atp7b modifies the hepatocytes’ response to copper overload in the mouse models of Wilson disease

Wilson disease (WD) is caused by inactivation of the copper transporter Atp7b and copper overload in tissues. Mice with Atp7b deleted either globally (systemic inactivation) or only in hepatocyte recapitulate various aspects of human disease. However, their phenotypes vary, and neither the common re...

Descripción completa

Detalles Bibliográficos
Autores principales: Muchenditsi, Abigael, Talbot, C. Conover, Gottlieb, Aline, Yang, Haojun, Kang, Byunghak, Boronina, Tatiana, Cole, Robert, Wang, Li, Dev, Som, Hamilton, James P., Lutsenko, Svetlana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952580/
https://www.ncbi.nlm.nih.gov/pubmed/33707579
http://dx.doi.org/10.1038/s41598-021-84894-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952580/
https://www.ncbi.nlm.nih.gov/pubmed/33707579
http://dx.doi.org/10.1038/s41598-021-84894-3

Ejemplares similares