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Red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study
Accumulating evidence has implicated dietary factors as important risks for rheumatoid arthritis (RA) development, but analyses of the effects of red meat consumption on RA have yielded diverging results. The aim of this study was to explore the association between red meat and RA in a large-scale,...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952581/ https://www.ncbi.nlm.nih.gov/pubmed/33707573 http://dx.doi.org/10.1038/s41598-021-85035-6 |
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author | Jin, Jiayang Li, Jing Gan, Yuzhou Liu, Jiajia Zhao, Xiaozhen Chen, Jiali Zhang, Ruijun Zhong, Yan Chen, Xiaomei Wu, Lijun Xiang, Xiaohong Zhou, Yunshan He, Jing Guo, Jianping Liu, Xu Li, Zhanguo |
author_facet | Jin, Jiayang Li, Jing Gan, Yuzhou Liu, Jiajia Zhao, Xiaozhen Chen, Jiali Zhang, Ruijun Zhong, Yan Chen, Xiaomei Wu, Lijun Xiang, Xiaohong Zhou, Yunshan He, Jing Guo, Jianping Liu, Xu Li, Zhanguo |
author_sort | Jin, Jiayang |
collection | PubMed |
description | Accumulating evidence has implicated dietary factors as important risks for rheumatoid arthritis (RA) development, but analyses of the effects of red meat consumption on RA have yielded diverging results. The aim of this study was to explore the association between red meat and RA in a large-scale, cross-sectional study. From June to December 2016, a total of 733 patients were investigated, from which 707 participants were included in the analysis. These patients were divided into two groups according to their consumption of red meat (< 100 g/day; ≥ 100 g/day). The intake of red meat was assessed via physician-administered questionnaire. Generalized linear models were used to analyze relationships between the red meat intake and RA, adjusting for potential confounders including demographic, clinical, laboratory, and other dietary factors. Compared with low-intake red meat RA patients, high-intake red meat patients had an earlier onset age (p = 0.02) and had higher BMI (p = 0.003). The age at disease onset for the high-intake patients was 6.46 years earlier than for low-intake patients, after adjustment for demographic and other possible confounders (β = − 6.46, 95% CI − 9.77, − 3.15; p = 0.0001). Further, stratified analyses showed that this inverse association of red meat intake with RA onset age was especially evident in smokers and overweight patients (BMI ≥ 24 kg/m(2)). In conclusion, high-intake red meat is associated with early onset of RA, especially in smokers or overweight patients. The findings indicate that eating less red meat could be a recommendation given to patients at risk for RA development. |
format | Online Article Text |
id | pubmed-7952581 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-79525812021-03-12 Red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study Jin, Jiayang Li, Jing Gan, Yuzhou Liu, Jiajia Zhao, Xiaozhen Chen, Jiali Zhang, Ruijun Zhong, Yan Chen, Xiaomei Wu, Lijun Xiang, Xiaohong Zhou, Yunshan He, Jing Guo, Jianping Liu, Xu Li, Zhanguo Sci Rep Article Accumulating evidence has implicated dietary factors as important risks for rheumatoid arthritis (RA) development, but analyses of the effects of red meat consumption on RA have yielded diverging results. The aim of this study was to explore the association between red meat and RA in a large-scale, cross-sectional study. From June to December 2016, a total of 733 patients were investigated, from which 707 participants were included in the analysis. These patients were divided into two groups according to their consumption of red meat (< 100 g/day; ≥ 100 g/day). The intake of red meat was assessed via physician-administered questionnaire. Generalized linear models were used to analyze relationships between the red meat intake and RA, adjusting for potential confounders including demographic, clinical, laboratory, and other dietary factors. Compared with low-intake red meat RA patients, high-intake red meat patients had an earlier onset age (p = 0.02) and had higher BMI (p = 0.003). The age at disease onset for the high-intake patients was 6.46 years earlier than for low-intake patients, after adjustment for demographic and other possible confounders (β = − 6.46, 95% CI − 9.77, − 3.15; p = 0.0001). Further, stratified analyses showed that this inverse association of red meat intake with RA onset age was especially evident in smokers and overweight patients (BMI ≥ 24 kg/m(2)). In conclusion, high-intake red meat is associated with early onset of RA, especially in smokers or overweight patients. The findings indicate that eating less red meat could be a recommendation given to patients at risk for RA development. Nature Publishing Group UK 2021-03-11 /pmc/articles/PMC7952581/ /pubmed/33707573 http://dx.doi.org/10.1038/s41598-021-85035-6 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Jin, Jiayang Li, Jing Gan, Yuzhou Liu, Jiajia Zhao, Xiaozhen Chen, Jiali Zhang, Ruijun Zhong, Yan Chen, Xiaomei Wu, Lijun Xiang, Xiaohong Zhou, Yunshan He, Jing Guo, Jianping Liu, Xu Li, Zhanguo Red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study |
title | Red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study |
title_full | Red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study |
title_fullStr | Red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study |
title_full_unstemmed | Red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study |
title_short | Red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study |
title_sort | red meat intake is associated with early onset of rheumatoid arthritis: a cross-sectional study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952581/ https://www.ncbi.nlm.nih.gov/pubmed/33707573 http://dx.doi.org/10.1038/s41598-021-85035-6 |
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