Clinical Experience of Personalized Phage Therapy Against Carbapenem-Resistant Acinetobacter baumannii Lung Infection in a Patient With Chronic Obstructive Pulmonary Disease

Overuse of antibiotics in clinical medicine has contributed to the global spread of multidrug-resistant bacterial pathogens, including Acinetobacter baumannii. We present a case of an 88-year-old Chinese man who developed hospital-acquired pneumonia caused by carbapenem-resistant A. baumannii (CRAB)...

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Autores principales: Tan, Xin, Chen, Huaisheng, Zhang, Min, Zhao, Ying, Jiang, Yichun, Liu, Xueyan, Huang, Wei, Ma, Yingfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952606/
https://www.ncbi.nlm.nih.gov/pubmed/33718279
http://dx.doi.org/10.3389/fcimb.2021.631585
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author Tan, Xin
Chen, Huaisheng
Zhang, Min
Zhao, Ying
Jiang, Yichun
Liu, Xueyan
Huang, Wei
Ma, Yingfei
author_facet Tan, Xin
Chen, Huaisheng
Zhang, Min
Zhao, Ying
Jiang, Yichun
Liu, Xueyan
Huang, Wei
Ma, Yingfei
author_sort Tan, Xin
collection PubMed
description Overuse of antibiotics in clinical medicine has contributed to the global spread of multidrug-resistant bacterial pathogens, including Acinetobacter baumannii. We present a case of an 88-year-old Chinese man who developed hospital-acquired pneumonia caused by carbapenem-resistant A. baumannii (CRAB). A personalized lytic pathogen-specific single-phage preparation was nebulized to the patient continuously for 16 days in combination with tigecycline and polymyxin E. The treatment was well tolerated and resulted in clearance of the pathogen and clinical improvement of the patient’s lung function.
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spelling pubmed-79526062021-03-13 Clinical Experience of Personalized Phage Therapy Against Carbapenem-Resistant Acinetobacter baumannii Lung Infection in a Patient With Chronic Obstructive Pulmonary Disease Tan, Xin Chen, Huaisheng Zhang, Min Zhao, Ying Jiang, Yichun Liu, Xueyan Huang, Wei Ma, Yingfei Front Cell Infect Microbiol Cellular and Infection Microbiology Overuse of antibiotics in clinical medicine has contributed to the global spread of multidrug-resistant bacterial pathogens, including Acinetobacter baumannii. We present a case of an 88-year-old Chinese man who developed hospital-acquired pneumonia caused by carbapenem-resistant A. baumannii (CRAB). A personalized lytic pathogen-specific single-phage preparation was nebulized to the patient continuously for 16 days in combination with tigecycline and polymyxin E. The treatment was well tolerated and resulted in clearance of the pathogen and clinical improvement of the patient’s lung function. Frontiers Media S.A. 2021-02-26 /pmc/articles/PMC7952606/ /pubmed/33718279 http://dx.doi.org/10.3389/fcimb.2021.631585 Text en Copyright © 2021 Tan, Chen, Zhang, Zhao, Jiang, Liu, Huang and Ma http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Tan, Xin
Chen, Huaisheng
Zhang, Min
Zhao, Ying
Jiang, Yichun
Liu, Xueyan
Huang, Wei
Ma, Yingfei
Clinical Experience of Personalized Phage Therapy Against Carbapenem-Resistant Acinetobacter baumannii Lung Infection in a Patient With Chronic Obstructive Pulmonary Disease
title Clinical Experience of Personalized Phage Therapy Against Carbapenem-Resistant Acinetobacter baumannii Lung Infection in a Patient With Chronic Obstructive Pulmonary Disease
title_full Clinical Experience of Personalized Phage Therapy Against Carbapenem-Resistant Acinetobacter baumannii Lung Infection in a Patient With Chronic Obstructive Pulmonary Disease
title_fullStr Clinical Experience of Personalized Phage Therapy Against Carbapenem-Resistant Acinetobacter baumannii Lung Infection in a Patient With Chronic Obstructive Pulmonary Disease
title_full_unstemmed Clinical Experience of Personalized Phage Therapy Against Carbapenem-Resistant Acinetobacter baumannii Lung Infection in a Patient With Chronic Obstructive Pulmonary Disease
title_short Clinical Experience of Personalized Phage Therapy Against Carbapenem-Resistant Acinetobacter baumannii Lung Infection in a Patient With Chronic Obstructive Pulmonary Disease
title_sort clinical experience of personalized phage therapy against carbapenem-resistant acinetobacter baumannii lung infection in a patient with chronic obstructive pulmonary disease
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952606/
https://www.ncbi.nlm.nih.gov/pubmed/33718279
http://dx.doi.org/10.3389/fcimb.2021.631585
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