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Wernicke Encephalopathy in COVID-19 Patients: Report of Three Cases

Encephalopathy has been frequently reported in patients with acute respiratory distress syndrome (ARDS) related to COVID-19, and its etiology remains undetermined. These patients display hypercatabolic state, weight loss, use of diuretics, and dialytic therapy, which represent risk factors for thiam...

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Autores principales: Branco de Oliveira, Marcus Vinicius, Bernabé, Daniel Galera, Irikura, Sergio, Irikura, Rodrigo Batista, Fontanelli, Antônio Mendes, Gonçalves, Marcus Vinícius Magno
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952637/
https://www.ncbi.nlm.nih.gov/pubmed/33716929
http://dx.doi.org/10.3389/fneur.2021.629273
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author Branco de Oliveira, Marcus Vinicius
Bernabé, Daniel Galera
Irikura, Sergio
Irikura, Rodrigo Batista
Fontanelli, Antônio Mendes
Gonçalves, Marcus Vinícius Magno
author_facet Branco de Oliveira, Marcus Vinicius
Bernabé, Daniel Galera
Irikura, Sergio
Irikura, Rodrigo Batista
Fontanelli, Antônio Mendes
Gonçalves, Marcus Vinícius Magno
author_sort Branco de Oliveira, Marcus Vinicius
collection PubMed
description Encephalopathy has been frequently reported in patients with acute respiratory distress syndrome (ARDS) related to COVID-19, and its etiology remains undetermined. These patients display hypercatabolic state, weight loss, use of diuretics, and dialytic therapy, which represent risk factors for thiamine depletion. The diagnosis of Wernicke encephalopathy (WE) is challenging and based on risk factors for the depletion of thiamine. We reported three cases of patients with COVID-19-related WE treated with intravenous thiamine. All patients responded with immediate neurologic improvement, and two of them had accelerated ventilatory weaning. The cases reported suggest that thiamine deficiency could represent relevant etiology of COVID-19-related encephalopathy.
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spelling pubmed-79526372021-03-13 Wernicke Encephalopathy in COVID-19 Patients: Report of Three Cases Branco de Oliveira, Marcus Vinicius Bernabé, Daniel Galera Irikura, Sergio Irikura, Rodrigo Batista Fontanelli, Antônio Mendes Gonçalves, Marcus Vinícius Magno Front Neurol Neurology Encephalopathy has been frequently reported in patients with acute respiratory distress syndrome (ARDS) related to COVID-19, and its etiology remains undetermined. These patients display hypercatabolic state, weight loss, use of diuretics, and dialytic therapy, which represent risk factors for thiamine depletion. The diagnosis of Wernicke encephalopathy (WE) is challenging and based on risk factors for the depletion of thiamine. We reported three cases of patients with COVID-19-related WE treated with intravenous thiamine. All patients responded with immediate neurologic improvement, and two of them had accelerated ventilatory weaning. The cases reported suggest that thiamine deficiency could represent relevant etiology of COVID-19-related encephalopathy. Frontiers Media S.A. 2021-02-26 /pmc/articles/PMC7952637/ /pubmed/33716929 http://dx.doi.org/10.3389/fneur.2021.629273 Text en Copyright © 2021 Branco de Oliveira, Bernabé, Irikura, Irikura, Fontanelli and Gonçalves. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Branco de Oliveira, Marcus Vinicius
Bernabé, Daniel Galera
Irikura, Sergio
Irikura, Rodrigo Batista
Fontanelli, Antônio Mendes
Gonçalves, Marcus Vinícius Magno
Wernicke Encephalopathy in COVID-19 Patients: Report of Three Cases
title Wernicke Encephalopathy in COVID-19 Patients: Report of Three Cases
title_full Wernicke Encephalopathy in COVID-19 Patients: Report of Three Cases
title_fullStr Wernicke Encephalopathy in COVID-19 Patients: Report of Three Cases
title_full_unstemmed Wernicke Encephalopathy in COVID-19 Patients: Report of Three Cases
title_short Wernicke Encephalopathy in COVID-19 Patients: Report of Three Cases
title_sort wernicke encephalopathy in covid-19 patients: report of three cases
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952637/
https://www.ncbi.nlm.nih.gov/pubmed/33716929
http://dx.doi.org/10.3389/fneur.2021.629273
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