mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

Glutathione peroxidase 4 (GPX4) utilizes glutathione (GSH) to detoxify lipid peroxidation and plays an essential role in inhibiting ferroptosis. As a selenoprotein, GPX4 protein synthesis is highly inefficient and energetically costly. How cells coordinate GPX4 synthesis with nutrient availability r...

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Detalles Bibliográficos
Autores principales: Zhang, Yilei, Swanda, Robert V., Nie, Litong, Liu, Xiaoguang, Wang, Chao, Lee, Hyemin, Lei, Guang, Mao, Chao, Koppula, Pranavi, Cheng, Weijie, Zhang, Jie, Xiao, Zhenna, Zhuang, Li, Fang, Bingliang, Chen, Junjie, Qian, Shu-Bing, Gan, Boyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952727/
https://www.ncbi.nlm.nih.gov/pubmed/33707434
http://dx.doi.org/10.1038/s41467-021-21841-w

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