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The Role of NKG2D in Vitiligo
Vitiligo is an acquired multifactorial disease that affects melanocytes and results in skin depigmentation. In this review, we examine the role of cells stress and self-reactive T cells responses. Given the canonical and non-canonical functions of NKG2D, such as authenticating stressed target and en...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952755/ https://www.ncbi.nlm.nih.gov/pubmed/33717132 http://dx.doi.org/10.3389/fimmu.2021.624131 |
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author | Plaza-Rojas, Lourdes Guevara-Patiño, José A. |
author_facet | Plaza-Rojas, Lourdes Guevara-Patiño, José A. |
author_sort | Plaza-Rojas, Lourdes |
collection | PubMed |
description | Vitiligo is an acquired multifactorial disease that affects melanocytes and results in skin depigmentation. In this review, we examine the role of cells stress and self-reactive T cells responses. Given the canonical and non-canonical functions of NKG2D, such as authenticating stressed target and enhance TCR signaling, we examine how melanocyte stress leads to the expression of ligands that are recognized by the activating receptor NKG2D, and how its signaling results in the turning of T cells against self (melanocyte suicide by proxy). We also discuss how this initiation phase is followed by T cell perpetuation, as NKG2D signaling results in self-sustained long-lasting T cells, with improved cytolytic properties. |
format | Online Article Text |
id | pubmed-7952755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79527552021-03-13 The Role of NKG2D in Vitiligo Plaza-Rojas, Lourdes Guevara-Patiño, José A. Front Immunol Immunology Vitiligo is an acquired multifactorial disease that affects melanocytes and results in skin depigmentation. In this review, we examine the role of cells stress and self-reactive T cells responses. Given the canonical and non-canonical functions of NKG2D, such as authenticating stressed target and enhance TCR signaling, we examine how melanocyte stress leads to the expression of ligands that are recognized by the activating receptor NKG2D, and how its signaling results in the turning of T cells against self (melanocyte suicide by proxy). We also discuss how this initiation phase is followed by T cell perpetuation, as NKG2D signaling results in self-sustained long-lasting T cells, with improved cytolytic properties. Frontiers Media S.A. 2021-02-26 /pmc/articles/PMC7952755/ /pubmed/33717132 http://dx.doi.org/10.3389/fimmu.2021.624131 Text en Copyright © 2021 Plaza-Rojas and Guevara-Patiño. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Plaza-Rojas, Lourdes Guevara-Patiño, José A. The Role of NKG2D in Vitiligo |
title | The Role of NKG2D in Vitiligo |
title_full | The Role of NKG2D in Vitiligo |
title_fullStr | The Role of NKG2D in Vitiligo |
title_full_unstemmed | The Role of NKG2D in Vitiligo |
title_short | The Role of NKG2D in Vitiligo |
title_sort | role of nkg2d in vitiligo |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952755/ https://www.ncbi.nlm.nih.gov/pubmed/33717132 http://dx.doi.org/10.3389/fimmu.2021.624131 |
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