Cargando…
“Lighten This Burden of Ours”: Acceptability and Preferences Regarding Injectable Antiretroviral Treatment Among Adults and Youth Living With HIV in Coastal Kenya
BACKGROUND: Long-acting injectable (LAI) antiretroviral therapy (ART) may offer persons living with HIV (PLWH) an attractive alternative to pill-based treatment options, yet acceptability data remain scant, especially in sub-Saharan Africa. METHODS: We conducted 6 focus group discussions with PLWH,...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952847/ https://www.ncbi.nlm.nih.gov/pubmed/33685272 http://dx.doi.org/10.1177/23259582211000517 |
_version_ | 1783663820859768832 |
---|---|
author | Simoni, Jane M. Beima-Sofie, Kristin Wanje, George Mohamed, Zahra H. Tapia, Kenneth McClelland, R. Scott Ho, Rodney J. Y. Collier, Ann C. Graham, Susan M. |
author_facet | Simoni, Jane M. Beima-Sofie, Kristin Wanje, George Mohamed, Zahra H. Tapia, Kenneth McClelland, R. Scott Ho, Rodney J. Y. Collier, Ann C. Graham, Susan M. |
author_sort | Simoni, Jane M. |
collection | PubMed |
description | BACKGROUND: Long-acting injectable (LAI) antiretroviral therapy (ART) may offer persons living with HIV (PLWH) an attractive alternative to pill-based treatment options, yet acceptability data remain scant, especially in sub-Saharan Africa. METHODS: We conducted 6 focus group discussions with PLWH, including key stake holder groups, and analyzed data with content analysis. RESULTS: Initial reactions to the idea of LAI-ART were often positive. The primary advantages voiced were potential to facilitate improved adherence and alleviate the burden of daily pill-taking while avoiding inadvertent disclosure and HIV stigma. Potential side effects were a particular concern of the women. Most participants preferred clinic-based administration over self-injections at home due to concerns about safety, privacy, and potential need for refrigeration. CONCLUSIONS: LAI-ART may be acceptable in Kenya, provided injections are infrequent and delivered in a clinic setting. However, HIV stigma, fear of potential side effects, and limited clinical capacity would need to be addressed. |
format | Online Article Text |
id | pubmed-7952847 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-79528472021-03-24 “Lighten This Burden of Ours”: Acceptability and Preferences Regarding Injectable Antiretroviral Treatment Among Adults and Youth Living With HIV in Coastal Kenya Simoni, Jane M. Beima-Sofie, Kristin Wanje, George Mohamed, Zahra H. Tapia, Kenneth McClelland, R. Scott Ho, Rodney J. Y. Collier, Ann C. Graham, Susan M. J Int Assoc Provid AIDS Care Original Research Article BACKGROUND: Long-acting injectable (LAI) antiretroviral therapy (ART) may offer persons living with HIV (PLWH) an attractive alternative to pill-based treatment options, yet acceptability data remain scant, especially in sub-Saharan Africa. METHODS: We conducted 6 focus group discussions with PLWH, including key stake holder groups, and analyzed data with content analysis. RESULTS: Initial reactions to the idea of LAI-ART were often positive. The primary advantages voiced were potential to facilitate improved adherence and alleviate the burden of daily pill-taking while avoiding inadvertent disclosure and HIV stigma. Potential side effects were a particular concern of the women. Most participants preferred clinic-based administration over self-injections at home due to concerns about safety, privacy, and potential need for refrigeration. CONCLUSIONS: LAI-ART may be acceptable in Kenya, provided injections are infrequent and delivered in a clinic setting. However, HIV stigma, fear of potential side effects, and limited clinical capacity would need to be addressed. SAGE Publications 2021-03-09 /pmc/articles/PMC7952847/ /pubmed/33685272 http://dx.doi.org/10.1177/23259582211000517 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Research Article Simoni, Jane M. Beima-Sofie, Kristin Wanje, George Mohamed, Zahra H. Tapia, Kenneth McClelland, R. Scott Ho, Rodney J. Y. Collier, Ann C. Graham, Susan M. “Lighten This Burden of Ours”: Acceptability and Preferences Regarding Injectable Antiretroviral Treatment Among Adults and Youth Living With HIV in Coastal Kenya |
title | “Lighten This Burden of Ours”: Acceptability and Preferences Regarding Injectable Antiretroviral Treatment Among Adults and Youth Living With HIV in Coastal Kenya |
title_full | “Lighten This Burden of Ours”: Acceptability and Preferences Regarding Injectable Antiretroviral Treatment Among Adults and Youth Living With HIV in Coastal Kenya |
title_fullStr | “Lighten This Burden of Ours”: Acceptability and Preferences Regarding Injectable Antiretroviral Treatment Among Adults and Youth Living With HIV in Coastal Kenya |
title_full_unstemmed | “Lighten This Burden of Ours”: Acceptability and Preferences Regarding Injectable Antiretroviral Treatment Among Adults and Youth Living With HIV in Coastal Kenya |
title_short | “Lighten This Burden of Ours”: Acceptability and Preferences Regarding Injectable Antiretroviral Treatment Among Adults and Youth Living With HIV in Coastal Kenya |
title_sort | “lighten this burden of ours”: acceptability and preferences regarding injectable antiretroviral treatment among adults and youth living with hiv in coastal kenya |
topic | Original Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952847/ https://www.ncbi.nlm.nih.gov/pubmed/33685272 http://dx.doi.org/10.1177/23259582211000517 |
work_keys_str_mv | AT simonijanem lightenthisburdenofoursacceptabilityandpreferencesregardinginjectableantiretroviraltreatmentamongadultsandyouthlivingwithhivincoastalkenya AT beimasofiekristin lightenthisburdenofoursacceptabilityandpreferencesregardinginjectableantiretroviraltreatmentamongadultsandyouthlivingwithhivincoastalkenya AT wanjegeorge lightenthisburdenofoursacceptabilityandpreferencesregardinginjectableantiretroviraltreatmentamongadultsandyouthlivingwithhivincoastalkenya AT mohamedzahrah lightenthisburdenofoursacceptabilityandpreferencesregardinginjectableantiretroviraltreatmentamongadultsandyouthlivingwithhivincoastalkenya AT tapiakenneth lightenthisburdenofoursacceptabilityandpreferencesregardinginjectableantiretroviraltreatmentamongadultsandyouthlivingwithhivincoastalkenya AT mcclellandrscott lightenthisburdenofoursacceptabilityandpreferencesregardinginjectableantiretroviraltreatmentamongadultsandyouthlivingwithhivincoastalkenya AT horodneyjy lightenthisburdenofoursacceptabilityandpreferencesregardinginjectableantiretroviraltreatmentamongadultsandyouthlivingwithhivincoastalkenya AT collierannc lightenthisburdenofoursacceptabilityandpreferencesregardinginjectableantiretroviraltreatmentamongadultsandyouthlivingwithhivincoastalkenya AT grahamsusanm lightenthisburdenofoursacceptabilityandpreferencesregardinginjectableantiretroviraltreatmentamongadultsandyouthlivingwithhivincoastalkenya |