Submission for Special Issue: The Role of Platelet Activation in the Pathophysiology of HIV, Tuberculosis, and Pneumococcal Disease. Bedaquiline Suppresses ADP-Mediated Activation of Human Platelets In Vitro via Interference With Phosphatidylinositol 3-Kinase

Although bedaquiline has advanced the treatment of multidrug-resistant tuberculosis (TB), concerns remain about the cardiotoxic potential of this agent, albeit by unexplored mechanisms. Accordingly, we have investigated augmentation of the reactivity of human platelets in vitro as a potential mechan...

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Detalles Bibliográficos
Autores principales: Tintinger, Gregory R., Theron, Annette J., Steel, Helen C., Cholo, Moloko C., Nel, Jan G., Feldman, Charles, Anderson, Ronald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952968/
https://www.ncbi.nlm.nih.gov/pubmed/33717055
http://dx.doi.org/10.3389/fimmu.2020.621148

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7952968/
https://www.ncbi.nlm.nih.gov/pubmed/33717055
http://dx.doi.org/10.3389/fimmu.2020.621148

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