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Integration of Nutrient Sensing in Fish Hypothalamus
The knowledge regarding hypothalamic integration of metabolic and endocrine signaling resulting in regulation of food intake is scarce in fish. Available studies pointed to a network in which the activation of the nutrient-sensing (glucose, fatty acid, and amino acid) systems would result in AMP-act...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2021
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953060/ https://www.ncbi.nlm.nih.gov/pubmed/33716662 http://dx.doi.org/10.3389/fnins.2021.653928 |
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author | Soengas, José L. |
author_facet | Soengas, José L. |
author_sort | Soengas, José L. |
collection | PubMed |
description | The knowledge regarding hypothalamic integration of metabolic and endocrine signaling resulting in regulation of food intake is scarce in fish. Available studies pointed to a network in which the activation of the nutrient-sensing (glucose, fatty acid, and amino acid) systems would result in AMP-activated protein kinase (AMPK) inhibition and activation of protein kinase B (Akt) and mechanistic target of rapamycin (mTOR). Changes in these signaling pathways would control phosphorylation of transcription factors cAMP response-element binding protein (CREB), forkhead box01 (FoxO1), and brain homeobox transcription factor (BSX) leading to food intake inhibition through changes in the expression of neuropeptide Y (NPY), agouti-related peptide (AgRP), pro-opio melanocortin (POMC), and cocaine and amphetamine-related transcript (CART). The present mini-review summarizes information on the topic and identifies gaps for future research. |
format | Online Article Text |
id | pubmed-7953060 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79530602021-03-13 Integration of Nutrient Sensing in Fish Hypothalamus Soengas, José L. Front Neurosci Neuroscience The knowledge regarding hypothalamic integration of metabolic and endocrine signaling resulting in regulation of food intake is scarce in fish. Available studies pointed to a network in which the activation of the nutrient-sensing (glucose, fatty acid, and amino acid) systems would result in AMP-activated protein kinase (AMPK) inhibition and activation of protein kinase B (Akt) and mechanistic target of rapamycin (mTOR). Changes in these signaling pathways would control phosphorylation of transcription factors cAMP response-element binding protein (CREB), forkhead box01 (FoxO1), and brain homeobox transcription factor (BSX) leading to food intake inhibition through changes in the expression of neuropeptide Y (NPY), agouti-related peptide (AgRP), pro-opio melanocortin (POMC), and cocaine and amphetamine-related transcript (CART). The present mini-review summarizes information on the topic and identifies gaps for future research. Frontiers Media S.A. 2021-02-26 /pmc/articles/PMC7953060/ /pubmed/33716662 http://dx.doi.org/10.3389/fnins.2021.653928 Text en Copyright © 2021 Soengas. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Soengas, José L. Integration of Nutrient Sensing in Fish Hypothalamus |
title | Integration of Nutrient Sensing in Fish Hypothalamus |
title_full | Integration of Nutrient Sensing in Fish Hypothalamus |
title_fullStr | Integration of Nutrient Sensing in Fish Hypothalamus |
title_full_unstemmed | Integration of Nutrient Sensing in Fish Hypothalamus |
title_short | Integration of Nutrient Sensing in Fish Hypothalamus |
title_sort | integration of nutrient sensing in fish hypothalamus |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953060/ https://www.ncbi.nlm.nih.gov/pubmed/33716662 http://dx.doi.org/10.3389/fnins.2021.653928 |
work_keys_str_mv | AT soengasjosel integrationofnutrientsensinginfishhypothalamus |