FLI1 Induces Megakaryopoiesis Gene Expression Through WAS/WIP-Dependent and Independent Mechanisms; Implications for Wiskott-Aldrich Syndrome

Wiskott–Aldrich Syndrome, WAS/WAVE, is a rare, X-linked immune-deficiency disease caused by mutations in the WAS gene, which together with its homolog, N-WASP, regulates actin cytoskeleton remodeling and cell motility. WAS patients suffer from microthrombocytopenia, characterized by a diminished num...

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Detalles Bibliográficos
Autores principales: Wang, Chunlin, Sample, Klarke M., Gajendran, Babu, Kapranov, Philipp, Liu, Wuling, Hu, Anling, Zacksenhaus, Eldad, Li, Yanmei, Hao, Xiaojiang, Ben-David, Yaacov
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953068/
https://www.ncbi.nlm.nih.gov/pubmed/33717090
http://dx.doi.org/10.3389/fimmu.2021.607836

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