Cargando…

Autoimmune Addison's Disease as Part of the Autoimmune Polyglandular Syndrome Type 1: Historical Overview and Current Evidence

The autoimmune polyglandular syndrome type 1 (APS1) is caused by pathogenic variants of the autoimmune regulator (AIRE) gene, located in the chromosomal region 21q22.3. The related protein, AIRE, enhances thymic self-representation and immune self-tolerance by localization to chromatin and anchorage...

Descripción completa

Detalles Bibliográficos
Autores principales: Perniola, Roberto, Fierabracci, Alessandra, Falorni, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953157/
https://www.ncbi.nlm.nih.gov/pubmed/33717087
http://dx.doi.org/10.3389/fimmu.2021.606860
_version_ 1783663865638158336
author Perniola, Roberto
Fierabracci, Alessandra
Falorni, Alberto
author_facet Perniola, Roberto
Fierabracci, Alessandra
Falorni, Alberto
author_sort Perniola, Roberto
collection PubMed
description The autoimmune polyglandular syndrome type 1 (APS1) is caused by pathogenic variants of the autoimmune regulator (AIRE) gene, located in the chromosomal region 21q22.3. The related protein, AIRE, enhances thymic self-representation and immune self-tolerance by localization to chromatin and anchorage to multimolecular complexes involved in the initiation and post-initiation events of tissue-specific antigen-encoding gene transcription. Once synthesized, the self-antigens are presented to, and cause deletion of, the self-reactive thymocyte clones. The clinical diagnosis of APS1 is based on the classic triad idiopathic hypoparathyroidism (HPT)—chronic mucocutaneous candidiasis—autoimmune Addison's disease (AAD), though new criteria based on early non-endocrine manifestations have been proposed. HPT is in most cases the first endocrine component of the syndrome; however, APS1-associated AAD has received the most accurate biochemical, clinical, and immunological characterization. Here is a comprehensive review of the studies on APS1-associated AAD from initial case reports to the most recent scientific findings.
format Online
Article
Text
id pubmed-7953157
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-79531572021-03-13 Autoimmune Addison's Disease as Part of the Autoimmune Polyglandular Syndrome Type 1: Historical Overview and Current Evidence Perniola, Roberto Fierabracci, Alessandra Falorni, Alberto Front Immunol Immunology The autoimmune polyglandular syndrome type 1 (APS1) is caused by pathogenic variants of the autoimmune regulator (AIRE) gene, located in the chromosomal region 21q22.3. The related protein, AIRE, enhances thymic self-representation and immune self-tolerance by localization to chromatin and anchorage to multimolecular complexes involved in the initiation and post-initiation events of tissue-specific antigen-encoding gene transcription. Once synthesized, the self-antigens are presented to, and cause deletion of, the self-reactive thymocyte clones. The clinical diagnosis of APS1 is based on the classic triad idiopathic hypoparathyroidism (HPT)—chronic mucocutaneous candidiasis—autoimmune Addison's disease (AAD), though new criteria based on early non-endocrine manifestations have been proposed. HPT is in most cases the first endocrine component of the syndrome; however, APS1-associated AAD has received the most accurate biochemical, clinical, and immunological characterization. Here is a comprehensive review of the studies on APS1-associated AAD from initial case reports to the most recent scientific findings. Frontiers Media S.A. 2021-02-26 /pmc/articles/PMC7953157/ /pubmed/33717087 http://dx.doi.org/10.3389/fimmu.2021.606860 Text en Copyright © 2021 Perniola, Fierabracci and Falorni. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Perniola, Roberto
Fierabracci, Alessandra
Falorni, Alberto
Autoimmune Addison's Disease as Part of the Autoimmune Polyglandular Syndrome Type 1: Historical Overview and Current Evidence
title Autoimmune Addison's Disease as Part of the Autoimmune Polyglandular Syndrome Type 1: Historical Overview and Current Evidence
title_full Autoimmune Addison's Disease as Part of the Autoimmune Polyglandular Syndrome Type 1: Historical Overview and Current Evidence
title_fullStr Autoimmune Addison's Disease as Part of the Autoimmune Polyglandular Syndrome Type 1: Historical Overview and Current Evidence
title_full_unstemmed Autoimmune Addison's Disease as Part of the Autoimmune Polyglandular Syndrome Type 1: Historical Overview and Current Evidence
title_short Autoimmune Addison's Disease as Part of the Autoimmune Polyglandular Syndrome Type 1: Historical Overview and Current Evidence
title_sort autoimmune addison's disease as part of the autoimmune polyglandular syndrome type 1: historical overview and current evidence
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953157/
https://www.ncbi.nlm.nih.gov/pubmed/33717087
http://dx.doi.org/10.3389/fimmu.2021.606860
work_keys_str_mv AT perniolaroberto autoimmuneaddisonsdiseaseaspartoftheautoimmunepolyglandularsyndrometype1historicaloverviewandcurrentevidence
AT fierabraccialessandra autoimmuneaddisonsdiseaseaspartoftheautoimmunepolyglandularsyndrometype1historicaloverviewandcurrentevidence
AT falornialberto autoimmuneaddisonsdiseaseaspartoftheautoimmunepolyglandularsyndrometype1historicaloverviewandcurrentevidence