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Efficacy of the feed additive consisting of amprolium hydrochloride (COXAM (®)) for use in chickens for fattening and chickens reared for laying (Huvepharma N.V.)
Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the efficacy of amprolium hydrochloride (COXAM (®)) for chickens for fattening and chickens reared for laying. COXAM (®) is a...
Autores principales: | , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953173/ https://www.ncbi.nlm.nih.gov/pubmed/33737967 http://dx.doi.org/10.2903/j.efsa.2021.6457 |
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author | Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Dusemund, Birgit Fašmon Durjava, Mojca Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Gropp, Jürgen Rychen, Guido Holczknecht, Orsolya Vettori, Maria Vittoria |
author_facet | Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Dusemund, Birgit Fašmon Durjava, Mojca Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Gropp, Jürgen Rychen, Guido Holczknecht, Orsolya Vettori, Maria Vittoria |
collection | PubMed |
description | Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the efficacy of amprolium hydrochloride (COXAM (®)) for chickens for fattening and chickens reared for laying. COXAM (®) is a coccidiostat intended to be used to control coccidiosis in chickens for fattening and chickens reared for laying up to 12 weeks of age at a dose of 125 mg amprolium hydrochloride (HCl)/kg complete feed. In its former opinion, the FEEDAP Panel was not in the position to conclude on the efficacy of COXAM (®) for chickens for fattening and chickens reared for laying due to insufficient number of positive and significant effects on relevant parameters in one of the anticoccidial sensitivity tests (ASTs) evaluated. In the present submission, an additional AST has been provided by the applicant. In this study, challenge by an Eimeria inoculum of low pathogenicity indicated the coccidiostatic potential of amprolium HCl based on the reduction of intestinal lesions. Considering the results of three floor pen trials and two ASTs described and assessed in a previous EFSA opinion and taking into account the newly submitted AST, the FEEDAP Panel concludes that COXAM (®) is efficacious in controlling coccidiosis in chickens for fattening at a dose of 125 mg amprolium HCl/kg complete feed. This conclusion is extended to chickens reared for laying. |
format | Online Article Text |
id | pubmed-7953173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-79531732021-03-17 Efficacy of the feed additive consisting of amprolium hydrochloride (COXAM (®)) for use in chickens for fattening and chickens reared for laying (Huvepharma N.V.) Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Dusemund, Birgit Fašmon Durjava, Mojca Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Gropp, Jürgen Rychen, Guido Holczknecht, Orsolya Vettori, Maria Vittoria EFSA J Scientific Opinion Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the efficacy of amprolium hydrochloride (COXAM (®)) for chickens for fattening and chickens reared for laying. COXAM (®) is a coccidiostat intended to be used to control coccidiosis in chickens for fattening and chickens reared for laying up to 12 weeks of age at a dose of 125 mg amprolium hydrochloride (HCl)/kg complete feed. In its former opinion, the FEEDAP Panel was not in the position to conclude on the efficacy of COXAM (®) for chickens for fattening and chickens reared for laying due to insufficient number of positive and significant effects on relevant parameters in one of the anticoccidial sensitivity tests (ASTs) evaluated. In the present submission, an additional AST has been provided by the applicant. In this study, challenge by an Eimeria inoculum of low pathogenicity indicated the coccidiostatic potential of amprolium HCl based on the reduction of intestinal lesions. Considering the results of three floor pen trials and two ASTs described and assessed in a previous EFSA opinion and taking into account the newly submitted AST, the FEEDAP Panel concludes that COXAM (®) is efficacious in controlling coccidiosis in chickens for fattening at a dose of 125 mg amprolium HCl/kg complete feed. This conclusion is extended to chickens reared for laying. John Wiley and Sons Inc. 2021-03-12 /pmc/articles/PMC7953173/ /pubmed/33737967 http://dx.doi.org/10.2903/j.efsa.2021.6457 Text en © 2021 European Food Safety Authority. EFSA Journal published by John Wiley and Sons Ltd on behalf of European Food Safety Authority. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made. |
spellingShingle | Scientific Opinion Bampidis, Vasileios Azimonti, Giovanna Bastos, Maria de Lourdes Christensen, Henrik Dusemund, Birgit Fašmon Durjava, Mojca Kouba, Maryline López‐Alonso, Marta López Puente, Secundino Marcon, Francesca Mayo, Baltasar Pechová, Alena Petkova, Mariana Ramos, Fernando Sanz, Yolanda Villa, Roberto Edoardo Woutersen, Ruud Gropp, Jürgen Rychen, Guido Holczknecht, Orsolya Vettori, Maria Vittoria Efficacy of the feed additive consisting of amprolium hydrochloride (COXAM (®)) for use in chickens for fattening and chickens reared for laying (Huvepharma N.V.) |
title | Efficacy of the feed additive consisting of amprolium hydrochloride (COXAM
(®)) for use in chickens for fattening and chickens reared for laying (Huvepharma N.V.) |
title_full | Efficacy of the feed additive consisting of amprolium hydrochloride (COXAM
(®)) for use in chickens for fattening and chickens reared for laying (Huvepharma N.V.) |
title_fullStr | Efficacy of the feed additive consisting of amprolium hydrochloride (COXAM
(®)) for use in chickens for fattening and chickens reared for laying (Huvepharma N.V.) |
title_full_unstemmed | Efficacy of the feed additive consisting of amprolium hydrochloride (COXAM
(®)) for use in chickens for fattening and chickens reared for laying (Huvepharma N.V.) |
title_short | Efficacy of the feed additive consisting of amprolium hydrochloride (COXAM
(®)) for use in chickens for fattening and chickens reared for laying (Huvepharma N.V.) |
title_sort | efficacy of the feed additive consisting of amprolium hydrochloride (coxam
(®)) for use in chickens for fattening and chickens reared for laying (huvepharma n.v.) |
topic | Scientific Opinion |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953173/ https://www.ncbi.nlm.nih.gov/pubmed/33737967 http://dx.doi.org/10.2903/j.efsa.2021.6457 |
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