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The relation of anatomical distribution of symptomatic peripheral arterial disease (PAD) with HbA1c level in patients with type 2 diabetes mellitus

AIMS: Increased level of glycated hemoglobin (HbA1c) is associated with an increased prevalence of peripheral arterial disease (PAD). This study aimed to assess the relationship between the anatomical distribution of symptomatic PAD lesions in patients with type 2 diabetes and HbA1c levels at the ti...

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Autores principales: Shatnawi, Nawaf J., Al-Zoubi, Nabil A., Hawamdeh, Hassan M., Khader, Yousef S., Heis, Mowafeq, Al Omari, Mamoon, Bataineh, Bassem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953225/
https://www.ncbi.nlm.nih.gov/pubmed/33767809
http://dx.doi.org/10.1177/20420188211000504
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author Shatnawi, Nawaf J.
Al-Zoubi, Nabil A.
Hawamdeh, Hassan M.
Khader, Yousef S.
Heis, Mowafeq
Al Omari, Mamoon
Bataineh, Bassem
author_facet Shatnawi, Nawaf J.
Al-Zoubi, Nabil A.
Hawamdeh, Hassan M.
Khader, Yousef S.
Heis, Mowafeq
Al Omari, Mamoon
Bataineh, Bassem
author_sort Shatnawi, Nawaf J.
collection PubMed
description AIMS: Increased level of glycated hemoglobin (HbA1c) is associated with an increased prevalence of peripheral arterial disease (PAD). This study aimed to assess the relationship between the anatomical distribution of symptomatic PAD lesions in patients with type 2 diabetes and HbA1c levels at the time of PAD diagnosis. PATIENTS AND METHODS: A retrospective study was conducted at King Abdullah University Hospital during the period August 2011 to December 2015. Consecutive patients with type 2 diabetes presented with symptomatic PAD confirmed by computed tomography-angiography (CTA) were included in this study. CTA images were reviewed. Relevant information including demographic data, PAD symptoms, comorbidities, HbA1c level, lipid profile, C-reactive protein and the mean platelets volume were retrieved from medical records. RESULTS: A total of 332 patients with type 2 diabetes (255 males and 77 females) were included in this study. The mean HbA1c at the time of PAD diagnosis was 8.68% (±2.06%). The prevalence of hemodynamic relevant atherosclerotic lesions of the superficial femoral artery, popliteal artery, leg vessels, femoro-popliteal, and crural segments was significantly higher in patients with HbA1c >7.5% compared with patients with HbA1c ⩽7.5%. CONCLUSION: The anatomical distribution of symptomatic PAD in patients with type 2 diabetes mellitus differed significantly according to HbA1c level at the time of PAD diagnosis.
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spelling pubmed-79532252021-03-24 The relation of anatomical distribution of symptomatic peripheral arterial disease (PAD) with HbA1c level in patients with type 2 diabetes mellitus Shatnawi, Nawaf J. Al-Zoubi, Nabil A. Hawamdeh, Hassan M. Khader, Yousef S. Heis, Mowafeq Al Omari, Mamoon Bataineh, Bassem Ther Adv Endocrinol Metab Original Research AIMS: Increased level of glycated hemoglobin (HbA1c) is associated with an increased prevalence of peripheral arterial disease (PAD). This study aimed to assess the relationship between the anatomical distribution of symptomatic PAD lesions in patients with type 2 diabetes and HbA1c levels at the time of PAD diagnosis. PATIENTS AND METHODS: A retrospective study was conducted at King Abdullah University Hospital during the period August 2011 to December 2015. Consecutive patients with type 2 diabetes presented with symptomatic PAD confirmed by computed tomography-angiography (CTA) were included in this study. CTA images were reviewed. Relevant information including demographic data, PAD symptoms, comorbidities, HbA1c level, lipid profile, C-reactive protein and the mean platelets volume were retrieved from medical records. RESULTS: A total of 332 patients with type 2 diabetes (255 males and 77 females) were included in this study. The mean HbA1c at the time of PAD diagnosis was 8.68% (±2.06%). The prevalence of hemodynamic relevant atherosclerotic lesions of the superficial femoral artery, popliteal artery, leg vessels, femoro-popliteal, and crural segments was significantly higher in patients with HbA1c >7.5% compared with patients with HbA1c ⩽7.5%. CONCLUSION: The anatomical distribution of symptomatic PAD in patients with type 2 diabetes mellitus differed significantly according to HbA1c level at the time of PAD diagnosis. SAGE Publications 2021-03-09 /pmc/articles/PMC7953225/ /pubmed/33767809 http://dx.doi.org/10.1177/20420188211000504 Text en © The Author(s), 2021 https://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Original Research
Shatnawi, Nawaf J.
Al-Zoubi, Nabil A.
Hawamdeh, Hassan M.
Khader, Yousef S.
Heis, Mowafeq
Al Omari, Mamoon
Bataineh, Bassem
The relation of anatomical distribution of symptomatic peripheral arterial disease (PAD) with HbA1c level in patients with type 2 diabetes mellitus
title The relation of anatomical distribution of symptomatic peripheral arterial disease (PAD) with HbA1c level in patients with type 2 diabetes mellitus
title_full The relation of anatomical distribution of symptomatic peripheral arterial disease (PAD) with HbA1c level in patients with type 2 diabetes mellitus
title_fullStr The relation of anatomical distribution of symptomatic peripheral arterial disease (PAD) with HbA1c level in patients with type 2 diabetes mellitus
title_full_unstemmed The relation of anatomical distribution of symptomatic peripheral arterial disease (PAD) with HbA1c level in patients with type 2 diabetes mellitus
title_short The relation of anatomical distribution of symptomatic peripheral arterial disease (PAD) with HbA1c level in patients with type 2 diabetes mellitus
title_sort relation of anatomical distribution of symptomatic peripheral arterial disease (pad) with hba1c level in patients with type 2 diabetes mellitus
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953225/
https://www.ncbi.nlm.nih.gov/pubmed/33767809
http://dx.doi.org/10.1177/20420188211000504
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