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Conformational Changes of Glutamine 5′-Phosphoribosylpyrophosphate Amidotransferase for Two Substrates Analogue Binding: Insight from Conventional Molecular Dynamics and Accelerated Molecular Dynamics Simulations

Glutamine 5′-phosphoribosylpyrophosphate amidotransferase (GPATase) catalyzes the synthesis of phosphoribosylamine, pyrophosphate, and glutamate from phosphoribosylpyrophosphate, as well as glutamine at two sites (i.e., glutaminase and phosphoribosylpyrophosphate sites), through a 20 Å NH(3) channel...

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Detalles Bibliográficos
Autores principales:	Li, Congcong, Chen, Siao, Huang, Tianci, Zhang, Fangning, Yuan, Jiawei, Chang, Hao, Li, Wannan, Han, Weiwei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953260/ https://www.ncbi.nlm.nih.gov/pubmed/33718330 http://dx.doi.org/10.3389/fchem.2021.640994

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