Targeting mechanosensitive MDM4 promotes lung fibrosis resolution in aged mice

Aging is a strong risk factor and an independent prognostic factor for progressive human idiopathic pulmonary fibrosis (IPF). Aged mice develop nonresolving pulmonary fibrosis following lung injury. In this study, we found that mouse double minute 4 homolog (MDM4) is highly expressed in the fibrotic...

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Detalles Bibliográficos
Autores principales: Qu, Jing, Yang, Shan-Zhong, Zhu, Yi, Guo, Ting, Thannickal, Victor J., Zhou, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953267/
https://www.ncbi.nlm.nih.gov/pubmed/33688918
http://dx.doi.org/10.1084/jem.20202033

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953267/
https://www.ncbi.nlm.nih.gov/pubmed/33688918
http://dx.doi.org/10.1084/jem.20202033

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