Sarbecovirus ORF6 proteins hamper induction of interferon signaling

The presence of an ORF6 gene distinguishes sarbecoviruses such as severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 from other betacoronaviruses. Here we show that ORF6 inhibits induction of innate immune signaling, including upregulation of type I interferon (IFN) upon viral i...

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Detalles Bibliográficos
Autores principales: Kimura, Izumi, Konno, Yoriyuki, Uriu, Keiya, Hopfensperger, Kristina, Sauter, Daniel, Nakagawa, So, Sato, Kei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Author(s). 2021
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953434/
https://www.ncbi.nlm.nih.gov/pubmed/33765414
http://dx.doi.org/10.1016/j.celrep.2021.108916

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953434/
https://www.ncbi.nlm.nih.gov/pubmed/33765414
http://dx.doi.org/10.1016/j.celrep.2021.108916

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