Extracellular vesicles from recombinant cell factories improve the activity and efficacy of enzymes defective in lysosomal storage disorders

In the present study the use of extracellular vesicles (EVs) as vehicles for therapeutic enzymes in lysosomal storage disorders was explored. EVs were isolated from mammalian cells overexpressing alpha‐galactosidase A (GLA) or N‐sulfoglucosamine sulfohydrolase (SGSH) enzymes, defective in Fabry and...

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Detalles Bibliográficos
Autores principales: Seras‐Franzoso, Joaquin, Díaz‐Riascos, Zamira V., Corchero, José Luis, González, Patricia, García‐Aranda, Natalia, Mandaña, Mònica, Riera, Roger, Boullosa, Ana, Mancilla, Sandra, Grayston, Alba, Moltó‐Abad, Marc, Garcia‐Fruitós, Elena, Mendoza, Rosa, Pintos‐Morell, Guillem, Albertazzi, Lorenzo, Rosell, Anna, Casas, Josefina, Villaverde, Antonio, Schwartz, Simó, Abasolo, Ibane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953474/
https://www.ncbi.nlm.nih.gov/pubmed/33738082
http://dx.doi.org/10.1002/jev2.12058

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