Tracking SARS-CoV-2 lineage B.1.1.7 dissemination: insights from nationwide spike gene target failure (SGTF) and spike gene late detection (SGTL) data, Portugal, week 49 2020 to week 3 2021

We show that the SARS-CoV-2 B.1.1.7 lineage is highly disseminated in Portugal, with the odds of B.1.1.7 proportion increasing at an estimated 89% (95% confidence interval: 83–95%) per week until week 3 2021. RT-PCR spike gene target late detection (SGTL) can constitute a useful surrogate to track B...

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Detalles Bibliográficos
Autores principales: Borges, Vítor, Sousa, Carlos, Menezes, Luís, Gonçalves, António Maia, Picão, Miguel, Almeida, José Pedro, Vieita, Margarida, Santos, Rafael, Silva, Ana Rita, Costa, Mariana, Carneiro, Luís, Casaca, Pedro, Pinto-Leite, Pedro, Peralta-Santos, André, Isidro, Joana, Duarte, Sílvia, Vieira, Luís, Guiomar, Raquel, Silva, Susana, Nunes, Baltazar, Gomes, João P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2021
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953529/
https://www.ncbi.nlm.nih.gov/pubmed/33706862
http://dx.doi.org/10.2807/1560-7917.ES.2021.26.10.2100130
Descripción
Sumario:We show that the SARS-CoV-2 B.1.1.7 lineage is highly disseminated in Portugal, with the odds of B.1.1.7 proportion increasing at an estimated 89% (95% confidence interval: 83–95%) per week until week 3 2021. RT-PCR spike gene target late detection (SGTL) can constitute a useful surrogate to track B.1.1.7 spread, besides the spike gene target failure (SGTF) proxy. SGTL/SGTF samples were associated with statistically significant higher viral loads, but not with substantial shift in age distribution compared to non-SGTF/SGTL cases.

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