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Tau antibody isotype induces differential effects following passive immunisation of tau transgenic mice

One of the main pathological hallmarks of Alzheimer’s disease (AD) is the intraneuronal accumulation of hyperphosphorylated tau. Passive immunotherapy is a promising strategy for the treatment of AD and there are currently a number of tau-specific monoclonal antibodies in clinical trials. A proposed...

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Detalles Bibliográficos
Autores principales:	Bajracharya, Rinie, Brici, David, Bodea, Liviu-Gabriel, Janowicz, Phillip W., Götz, Jürgen, Nisbet, Rebecca M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953551/ https://www.ncbi.nlm.nih.gov/pubmed/33712083 http://dx.doi.org/10.1186/s40478-021-01147-0

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