A Fas-4-1BB fusion protein converts a death to a pro-survival signal and enhances T cell therapy

Adoptive T cell therapy (ACT) with genetically modified T cells has shown impressive results against some hematologic cancers, but efficacy in solid tumors can be limited by restrictive tumor microenvironments (TMEs). For example, Fas ligand is commonly overexpressed in TMEs and induces apoptosis in...

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Detalles Bibliográficos
Autores principales: Oda, Shannon K., Anderson, Kristin G., Ravikumar, Pranali, Bonson, Patrick, Garcia, Nicolas M., Jenkins, Cody M., Zhuang, Summer, Daman, Andrew W., Chiu, Edison Y., Bates, Breanna M., Greenberg, Philip D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953733/
https://www.ncbi.nlm.nih.gov/pubmed/32860705
http://dx.doi.org/10.1084/jem.20191166

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