Affinity maturation is required for pathogenic monovalent IgG4 autoantibody development in myasthenia gravis

Pathogenic muscle-specific tyrosine kinase (MuSK)–specific IgG4 autoantibodies in autoimmune myasthenia gravis (MG) are functionally monovalent as a result of Fab-arm exchange. The development of these unique autoantibodies is not well understood. We examined MG patient–derived monoclonal autoantibo...

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Detalles Bibliográficos
Autores principales: Fichtner, Miriam L., Vieni, Casey, Redler, Rachel L., Kolich, Ljuvica, Jiang, Ruoyi, Takata, Kazushiro, Stathopoulos, Panos, Suarez, Pablo A., Nowak, Richard J., Burden, Steven J., Ekiert, Damian C., O’Connor, Kevin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953735/
https://www.ncbi.nlm.nih.gov/pubmed/32820331
http://dx.doi.org/10.1084/jem.20200513

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