APOBEC3A catalyzes mutation and drives carcinogenesis in vivo

The APOBEC3 family of antiviral DNA cytosine deaminases is implicated as the second largest source of mutation in cancer. This mutational process may be a causal driver or inconsequential passenger to the overall tumor phenotype. We show that human APOBEC3A expression in murine colon and liver tissu...

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Detalles Bibliográficos
Autores principales: Law, Emily K., Levin-Klein, Rena, Jarvis, Matthew C., Kim, Hyoung, Argyris, Prokopios P., Carpenter, Michael A., Starrett, Gabriel J., Temiz, Nuri A., Larson, Lindsay K., Durfee, Cameron, Burns, Michael B., Vogel, Rachel I., Stavrou, Spyridon, Aguilera, Alexya N., Wagner, Sandra, Largaespada, David A., Starr, Timothy K., Ross, Susan R., Harris, Reuben S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953736/
https://www.ncbi.nlm.nih.gov/pubmed/32870257
http://dx.doi.org/10.1084/jem.20200261

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