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Interleukin-17–induced neutrophil extracellular traps mediate resistance to checkpoint blockade in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) remains a lethal malignancy with an immunosuppressive microenvironment that is resistant to most therapies. IL17 is involved in pancreatic tumorigenesis, but its role in invasive PDAC is undetermined. We hypothesized that IL17 triggers and sustains PDAC immuno...

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Detalles Bibliográficos
Autores principales:	Zhang, Yu, Chandra, Vidhi, Riquelme Sanchez, Erick, Dutta, Prasanta, Quesada, Pompeyo R., Rakoski, Amanda, Zoltan, Michelle, Arora, Nivedita, Baydogan, Seyda, Horne, William, Burks, Jared, Xu, Hanwen, Hussain, Perwez, Wang, Huamin, Gupta, Sonal, Maitra, Anirban, Bailey, Jennifer M., Moghaddam, Seyed J., Banerjee, Sulagna, Sahin, Ismet, Bhattacharya, Pratip, McAllister, Florencia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953739/ https://www.ncbi.nlm.nih.gov/pubmed/32860704 http://dx.doi.org/10.1084/jem.20190354

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