Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE

Variations in many genes linked to sporadic Alzheimer’s disease (AD) show abundant expression in microglia, but relationships among these genes remain largely elusive. Here, we establish isogenic human ESC–derived microglia-like cell lines (hMGLs) harboring AD variants in CD33, INPP5D, SORL1, and TR...

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Detalles Bibliográficos
Autores principales: Liu, Tongfei, Zhu, Bing, Liu, Yan, Zhang, Xiaoming, Yin, Jun, Li, Xiaoguang, Jiang, LuLin, Hodges, Andrew P., Rosenthal, Sara Brin, Zhou, Lisa, Yancey, Joel, McQuade, Amanda, Blurton-Jones, Mathew, Tanzi, Rudolph E., Huang, Timothy Y., Xu, Huaxi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Technical Advances and Resources
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953740/
https://www.ncbi.nlm.nih.gov/pubmed/32941599
http://dx.doi.org/10.1084/jem.20200474

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