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Case Report: Adjuvant Radiotherapy Can Be an Effective Treatment for Intimal Sarcoma of the Heart

Intimal sarcoma of the heart is a sporadic disease, which involves symptoms of cardiac insufficiency due to a fast-growing intraluminal mass. Tumor resection is the first-line treatment, although its location precludes excision with wide uninvolved margins. Despite the aggressiveness of this neoplas...

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Autores principales: Romanowska, Anna, Lewicka, Ewa, Sławiński, Grzegorz, Jankowska, Hanna, Zaucha, Renata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953907/
https://www.ncbi.nlm.nih.gov/pubmed/33718180
http://dx.doi.org/10.3389/fonc.2021.621289
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author Romanowska, Anna
Lewicka, Ewa
Sławiński, Grzegorz
Jankowska, Hanna
Zaucha, Renata
author_facet Romanowska, Anna
Lewicka, Ewa
Sławiński, Grzegorz
Jankowska, Hanna
Zaucha, Renata
author_sort Romanowska, Anna
collection PubMed
description Intimal sarcoma of the heart is a sporadic disease, which involves symptoms of cardiac insufficiency due to a fast-growing intraluminal mass. Tumor resection is the first-line treatment, although its location precludes excision with wide uninvolved margins. Despite the aggressiveness of this neoplasm and a high risk of recurrence even after removal by microscopically radical surgery, no standard adjuvant therapy has been established. Chemotherapy is used either as an adjuvant treatment or in cases of advanced disease. In contrast, the use of radiotherapy is rare and usually considered in a palliative setting because the risk of radiation-induced heart disease after high-dose radiotherapy to the heart is significant. Herein, we present the cases of two patients, both diagnosed with cardiac intimal sarcoma, who received irradiation after tumor resection. In both cases, radiotherapy was effective, providing long-lasting local disease control. We regularly monitored cardiac function in both patients to assess the impact of radiotherapy on tumor-free heart structures. The excellent local control of the disease with only mild long-term cardiac dysfunction in both patients suggests that radiotherapy can be a useful treatment modality in this indication.
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spelling pubmed-79539072021-03-13 Case Report: Adjuvant Radiotherapy Can Be an Effective Treatment for Intimal Sarcoma of the Heart Romanowska, Anna Lewicka, Ewa Sławiński, Grzegorz Jankowska, Hanna Zaucha, Renata Front Oncol Oncology Intimal sarcoma of the heart is a sporadic disease, which involves symptoms of cardiac insufficiency due to a fast-growing intraluminal mass. Tumor resection is the first-line treatment, although its location precludes excision with wide uninvolved margins. Despite the aggressiveness of this neoplasm and a high risk of recurrence even after removal by microscopically radical surgery, no standard adjuvant therapy has been established. Chemotherapy is used either as an adjuvant treatment or in cases of advanced disease. In contrast, the use of radiotherapy is rare and usually considered in a palliative setting because the risk of radiation-induced heart disease after high-dose radiotherapy to the heart is significant. Herein, we present the cases of two patients, both diagnosed with cardiac intimal sarcoma, who received irradiation after tumor resection. In both cases, radiotherapy was effective, providing long-lasting local disease control. We regularly monitored cardiac function in both patients to assess the impact of radiotherapy on tumor-free heart structures. The excellent local control of the disease with only mild long-term cardiac dysfunction in both patients suggests that radiotherapy can be a useful treatment modality in this indication. Frontiers Media S.A. 2021-02-26 /pmc/articles/PMC7953907/ /pubmed/33718180 http://dx.doi.org/10.3389/fonc.2021.621289 Text en Copyright © 2021 Romanowska, Lewicka, Sławiński, Jankowska and Zaucha http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Romanowska, Anna
Lewicka, Ewa
Sławiński, Grzegorz
Jankowska, Hanna
Zaucha, Renata
Case Report: Adjuvant Radiotherapy Can Be an Effective Treatment for Intimal Sarcoma of the Heart
title Case Report: Adjuvant Radiotherapy Can Be an Effective Treatment for Intimal Sarcoma of the Heart
title_full Case Report: Adjuvant Radiotherapy Can Be an Effective Treatment for Intimal Sarcoma of the Heart
title_fullStr Case Report: Adjuvant Radiotherapy Can Be an Effective Treatment for Intimal Sarcoma of the Heart
title_full_unstemmed Case Report: Adjuvant Radiotherapy Can Be an Effective Treatment for Intimal Sarcoma of the Heart
title_short Case Report: Adjuvant Radiotherapy Can Be an Effective Treatment for Intimal Sarcoma of the Heart
title_sort case report: adjuvant radiotherapy can be an effective treatment for intimal sarcoma of the heart
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953907/
https://www.ncbi.nlm.nih.gov/pubmed/33718180
http://dx.doi.org/10.3389/fonc.2021.621289
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