Cargando…

Oxygen Deprivation Modulates EGFR and PD-L1 in Squamous Cell Carcinomas of the Head and Neck

Abundance and signaling of the epidermal growth factor receptor (EGFR) and programmed cell death protein ligand 1 (PD-L1) in head and neck squamous cell carcinoma (HNSCC) are not only genetically determined but are also subject to the traits of the tumor microenvironment, which has hitherto not been...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zahnreich, Sebastian, Gebrekidan, Senayit, Multhoff, Gabriele, Vaupel, Peter, Schmidberger, Heinz, Mayer, Arnulf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Oncology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7953989/ https://www.ncbi.nlm.nih.gov/pubmed/33718186 http://dx.doi.org/10.3389/fonc.2021.623964

Ejemplares similares

Downregulation of EGFR in hypoxic, diffusion-limited areas of squamous cell carcinomas of the head and neck
por: Mayer, Arnulf, et al.
Publicado: (2016)

The cGAS/STING/IFN-1 Response in Squamous Head and Neck Cancer Cells after Genotoxic Challenges and Abrogation of the ATR-Chk1 and Fanconi Anemia Axis
por: Zahnreich, Sebastian, et al.
Publicado: (2023)

GLUT-1 expression is largely unrelated to both hypoxia and the Warburg phenotype in squamous cell carcinomas of the vulva
por: Mayer, Arnulf, et al.
Publicado: (2014)

Childhood Cancer: Occurrence, Treatment and Risk of Second Primary Malignancies
por: Zahnreich, Sebastian, et al.
Publicado: (2021)

Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma
por: MAYER, ARNULF, et al.
Publicado: (2012)

Adjuvant chemoradiotherapy in elderly patients with head and neck cancer: a monoinstitutional, two-to-one pair-matching analysis
por: Mayer, Arnulf, et al.
Publicado: (2022)

EGFR Mutations in Head and Neck Squamous Cell Carcinoma
por: Nair, Sindhu, et al.
Publicado: (2022)

Using the R Package Spatstat to Assess Inhibitory Effects of Microregional Hypoxia on the Infiltration of Cancers of the Head and Neck Region by Cytotoxic T Lymphocytes
por: Kaufmann, Justus, et al.
Publicado: (2021)

Study of EGFR mutations in head and neck squamous cell carcinomas
por: Kaur, Gurpreet, et al.
Publicado: (2021)

Role of Hypoxia and the Adenosine System in Immune Evasion and Prognosis of Patients with Brain Metastases of Melanoma: A Multiplex Whole Slide Immunofluorescence Study
por: Mayer, Arnulf, et al.
Publicado: (2020)

Radiation-induced DNA double-strand breaks in peripheral leukocytes and therapeutic response of heel spur patients treated by orthovoltage X-rays or a linear accelerator
por: Zahnreich, Sebastian, et al.
Publicado: (2020)

Radiation-induced changes in microcirculation and interstitial fluid pressure affecting the delivery of macromolecules and nanotherapeutics to tumors
por: Multhoff, Gabriele, et al.
Publicado: (2012)

Commentary: A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment
por: Vaupel, Peter, et al.
Publicado: (2016)

Accomplices of the Hypoxic Tumor Microenvironment Compromising Antitumor Immunity: Adenosine, Lactate, Acidosis, Vascular Endothelial Growth Factor, Potassium Ions, and Phosphatidylserine
por: Vaupel, Peter, et al.
Publicado: (2017)

Lactate-avid regulatory T cells: metabolic plasticity controls immunosuppression in tumour microenvironment
por: Multhoff, Gabriele, et al.
Publicado: (2021)

Present and Future of EGFR Inhibitors for Head and Neck Squamous Cell Cancer
por: Baba, Yuh, et al.
Publicado: (2012)

Prognostic and predictive value of EGFR in head and neck squamous cell carcinoma
por: Bossi, Paolo, et al.
Publicado: (2016)

EGFR modulates complement activation in head and neck squamous cell carcinoma
por: Abu-Humaidan, Anas H. A., et al.
Publicado: (2020)

EGFR-specific T cell frequencies correlate with EGFR expression in head and neck squamous cell carcinoma
por: Schuler, Patrick J, et al.
Publicado: (2011)

Addictions, Social Deprivation and Cessation Failure in Head and Neck Squamous Cell Carcinoma Survivors
por: Nokovitch, Lara, et al.
Publicado: (2023)

Radiochemotherapy combined with NK cell transfer followed by second-line PD-1 inhibition in a patient with NSCLC stage IIIb inducing long-term tumor control: a case study
por: Kokowski, Konrad, et al.
Publicado: (2019)

Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance
por: Multhoff, Gabriele, et al.
Publicado: (2014)

Tyrosine kinase domain mutations of EGFR gene in head and neck squamous cell carcinoma
por: Vatte, Chittibabu, et al.
Publicado: (2017)

EGFR in head and neck squamous cell carcinoma: exploring possibilities of novel drug combinations
por: Rehmani, Hina S., et al.
Publicado: (2020)

Evaluation of Concomitant Systemic Treatment in Older Adults With Head and Neck Squamous Cell Carcinoma Undergoing Definitive Radiotherapy
por: Rühle, Alexander, et al.
Publicado: (2023)

SKLB188 inhibits the growth of head and neck squamous cell carcinoma by suppressing EGFR signalling
por: Barzegar, Mansoureh, et al.
Publicado: (2017)

Effects of culture method on response to EGFR therapy in head and neck squamous cell carcinoma cells
por: Ayuso, Jose M., et al.
Publicado: (2019)

Gold Nanoparticles Enhance EGFR Inhibition and Irradiation Effects in Head and Neck Squamous Carcinoma Cells
por: Kashin, Masahiko, et al.
Publicado: (2020)

Antitumor Efficacy of EGFR-Targeted Recombinant Immunotoxin in Human Head and Neck Squamous Cell Carcinoma
por: Xie, Guiqin, et al.
Publicado: (2022)

Intratumor heterogeneity of PD-L1 expression in head and neck squamous cell carcinoma
por: Rasmussen, Jacob H., et al.
Publicado: (2019)

New approaches to EGFR inhibition for locally advanced or metastatic squamous cell carcinoma of the head and neck (SCCHN)
por: Agulnik, Mark
Publicado: (2012)

EGFR Monoclonal Antibodies in the Treatment of Squamous Cell Carcinoma of the Head and Neck: A View beyond Cetuximab
por: Kono, Scott A., et al.
Publicado: (2012)

Correlation between egfr expression and accelerated proliferation during radiotherapy of head and neck squamous cell carcinoma
por: Pedicini, Piernicola, et al.
Publicado: (2012)

FOXD1 Regulates the Sensitivity of Cetuximab by Regulating the Expression of EGFR in Head and Neck Squamous Cell Cancer
por: Mu, Lan, et al.
Publicado: (2022)

Small molecule profiling to define synergistic EGFR inhibitor combinations in head and neck squamous cell carcinoma
por: Michmerhuizen, Nicole L., et al.
Publicado: (2022)

EGFR Inhibition by Cetuximab Modulates Hypoxia and IFN Response Genes in Head and Neck Squamous Cell Carcinoma
por: Chaudhary, Ritu, et al.
Publicado: (2023)

PD-L1: a novel prognostic biomarker in head and neck squamous cell carcinoma
por: Müller, Tim, et al.
Publicado: (2017)

Tumor hypoxia is associated with resistance to PD-1 blockade in squamous cell carcinoma of the head and neck
por: Zandberg, Dan P, et al.
Publicado: (2021)

Performance of Different Diagnostic PD-L1 Clones in Head and Neck Squamous Cell Carcinoma
por: Ribbat-Idel, Julika, et al.
Publicado: (2021)

Co-targeting EGFR and IKKβ/NF-κB signalling pathways in head and neck squamous cell carcinoma: a potential novel therapy for head and neck squamous cell cancer
por: Li, Zhipeng, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_btg4bclfn777csr0elv3n3ntj1