Newly discovered neuron-to-glioma communication: new noninvasive therapeutic opportunities on the horizon?

The newly discovered functional integration of glioma cells into brain networks in mouse models provides groundbreaking insight into glioma aggressiveness and resistance to treatments, also suggesting novel potential therapeutic avenues and targets. In the context of such neuron-to-glioma communicat...

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Detalles Bibliográficos
Autores principales: Sprugnoli, Giulia, Golby, Alexandra J, Santarnecchi, Emiliano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954106/
https://www.ncbi.nlm.nih.gov/pubmed/33738449
http://dx.doi.org/10.1093/noajnl/vdab018
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author Sprugnoli, Giulia
Golby, Alexandra J
Santarnecchi, Emiliano
author_facet Sprugnoli, Giulia
Golby, Alexandra J
Santarnecchi, Emiliano
author_sort Sprugnoli, Giulia
collection PubMed
description The newly discovered functional integration of glioma cells into brain networks in mouse models provides groundbreaking insight into glioma aggressiveness and resistance to treatments, also suggesting novel potential therapeutic avenues and targets. In the context of such neuron-to-glioma communication, noninvasive brain modulation techniques traditionally applied to modulate neuronal function in neurological and psychiatric diseases (eg, increase/decrease cortical excitability and plasticity) could now be tested in patients with brain tumors to suppress glioma’s activity and its pathological crosstalk with healthy brain tissue.
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spelling pubmed-79541062021-03-17 Newly discovered neuron-to-glioma communication: new noninvasive therapeutic opportunities on the horizon? Sprugnoli, Giulia Golby, Alexandra J Santarnecchi, Emiliano Neurooncol Adv Reviews The newly discovered functional integration of glioma cells into brain networks in mouse models provides groundbreaking insight into glioma aggressiveness and resistance to treatments, also suggesting novel potential therapeutic avenues and targets. In the context of such neuron-to-glioma communication, noninvasive brain modulation techniques traditionally applied to modulate neuronal function in neurological and psychiatric diseases (eg, increase/decrease cortical excitability and plasticity) could now be tested in patients with brain tumors to suppress glioma’s activity and its pathological crosstalk with healthy brain tissue. Oxford University Press 2021-02-04 /pmc/articles/PMC7954106/ /pubmed/33738449 http://dx.doi.org/10.1093/noajnl/vdab018 Text en © The Author(s) 2021. Published by Oxford University Press, the Society for Neuro-Oncology and the European Association of Neuro-Oncology. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Sprugnoli, Giulia
Golby, Alexandra J
Santarnecchi, Emiliano
Newly discovered neuron-to-glioma communication: new noninvasive therapeutic opportunities on the horizon?
title Newly discovered neuron-to-glioma communication: new noninvasive therapeutic opportunities on the horizon?
title_full Newly discovered neuron-to-glioma communication: new noninvasive therapeutic opportunities on the horizon?
title_fullStr Newly discovered neuron-to-glioma communication: new noninvasive therapeutic opportunities on the horizon?
title_full_unstemmed Newly discovered neuron-to-glioma communication: new noninvasive therapeutic opportunities on the horizon?
title_short Newly discovered neuron-to-glioma communication: new noninvasive therapeutic opportunities on the horizon?
title_sort newly discovered neuron-to-glioma communication: new noninvasive therapeutic opportunities on the horizon?
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954106/
https://www.ncbi.nlm.nih.gov/pubmed/33738449
http://dx.doi.org/10.1093/noajnl/vdab018
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AT santarnecchiemiliano newlydiscoveredneurontogliomacommunicationnewnoninvasivetherapeuticopportunitiesonthehorizon

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