LSD1 enzyme inhibitor TAK-418 unlocks aberrant epigenetic machinery and improves autism symptoms in neurodevelopmental disorder models

Persistent epigenetic dysregulation may underlie the pathophysiology of neurodevelopmental disorders, such as autism spectrum disorder (ASD). Here, we show that the inhibition of lysine-specific demethylase 1 (LSD1) enzyme activity normalizes aberrant epigenetic control of gene expression in neurode...

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Detalles Bibliográficos
Autores principales: Baba, Rina, Matsuda, Satoru, Arakawa, Yuuichi, Yamada, Ryuji, Suzuki, Noriko, Ando, Tatsuya, Oki, Hideyuki, Igaki, Shigeru, Daini, Masaki, Hattori, Yasushi, Matsumoto, Shigemitsu, Ito, Mitsuhiro, Nakatani, Atsushi, Kimura, Haruhide
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954450/
https://www.ncbi.nlm.nih.gov/pubmed/33712455
http://dx.doi.org/10.1126/sciadv.aba1187

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