Injury-mediated stiffening persistently activates muscle stem cells through YAP and TAZ mechanotransduction

The skeletal muscle microenvironment transiently remodels and stiffens after exercise and injury, as muscle ages, and in myopathic muscle; however, how these changes in stiffness affect resident muscle stem cells (MuSCs) remains understudied. Following muscle injury, muscle stiffness remained elevat...

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Detalles Bibliográficos
Autores principales: Silver, Jason S., Günay, K. Arda, Cutler, Alicia A., Vogler, Thomas O., Brown, Tobin E., Pawlikowski, Bradley T., Bednarski, Olivia J., Bannister, Kendra L., Rogowski, Cameron J., Mckay, Austin G., DelRio, Frank W., Olwin, Bradley B., Anseth, Kristi S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2021
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954458/
https://www.ncbi.nlm.nih.gov/pubmed/33712460
http://dx.doi.org/10.1126/sciadv.abe4501

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