Dual Ni/photoredox-catalyzed asymmetric cross-coupling to access chiral benzylic boronic esters

The flourishing Ni/photoredox-catalyzed asymmetric couplings typically rely on redox-neutral reactions. In this work, we report a reductive cross-coupling of aryl iodides and α-chloroboranes under a dual catalytic regime to further enrich the metallaphotoredox chemistry. This approach proceeds under...

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Autores principales: Zheng, Purui, Zhou, Pan, Wang, Dong, Xu, Wenhao, Wang, Hepan, XU, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954797/
https://www.ncbi.nlm.nih.gov/pubmed/33712612
http://dx.doi.org/10.1038/s41467-021-21947-1
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author Zheng, Purui
Zhou, Pan
Wang, Dong
Xu, Wenhao
Wang, Hepan
XU, Tao
author_facet Zheng, Purui
Zhou, Pan
Wang, Dong
Xu, Wenhao
Wang, Hepan
XU, Tao
author_sort Zheng, Purui
collection PubMed
description The flourishing Ni/photoredox-catalyzed asymmetric couplings typically rely on redox-neutral reactions. In this work, we report a reductive cross-coupling of aryl iodides and α-chloroboranes under a dual catalytic regime to further enrich the metallaphotoredox chemistry. This approach proceeds under mild conditions (visible light, ambient temperature, no strong base) to access the versatile benzylic boronic esters with good functional group tolerance and excellent enantioselectivities.
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spelling pubmed-79547972021-03-28 Dual Ni/photoredox-catalyzed asymmetric cross-coupling to access chiral benzylic boronic esters Zheng, Purui Zhou, Pan Wang, Dong Xu, Wenhao Wang, Hepan XU, Tao Nat Commun Article The flourishing Ni/photoredox-catalyzed asymmetric couplings typically rely on redox-neutral reactions. In this work, we report a reductive cross-coupling of aryl iodides and α-chloroboranes under a dual catalytic regime to further enrich the metallaphotoredox chemistry. This approach proceeds under mild conditions (visible light, ambient temperature, no strong base) to access the versatile benzylic boronic esters with good functional group tolerance and excellent enantioselectivities. Nature Publishing Group UK 2021-03-12 /pmc/articles/PMC7954797/ /pubmed/33712612 http://dx.doi.org/10.1038/s41467-021-21947-1 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zheng, Purui
Zhou, Pan
Wang, Dong
Xu, Wenhao
Wang, Hepan
XU, Tao
Dual Ni/photoredox-catalyzed asymmetric cross-coupling to access chiral benzylic boronic esters
title Dual Ni/photoredox-catalyzed asymmetric cross-coupling to access chiral benzylic boronic esters
title_full Dual Ni/photoredox-catalyzed asymmetric cross-coupling to access chiral benzylic boronic esters
title_fullStr Dual Ni/photoredox-catalyzed asymmetric cross-coupling to access chiral benzylic boronic esters
title_full_unstemmed Dual Ni/photoredox-catalyzed asymmetric cross-coupling to access chiral benzylic boronic esters
title_short Dual Ni/photoredox-catalyzed asymmetric cross-coupling to access chiral benzylic boronic esters
title_sort dual ni/photoredox-catalyzed asymmetric cross-coupling to access chiral benzylic boronic esters
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954797/
https://www.ncbi.nlm.nih.gov/pubmed/33712612
http://dx.doi.org/10.1038/s41467-021-21947-1
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