Progress in the risk assessment of hydroxychloroquine in frail elderly people

Hydroxychloroquine (HCQ) is an antimalarial drug also known to have anti‐inflammatory and antiviral effects. The antiviral action of HCQ has been a point of interest for many researchers because of its mechanism of action and the potential use it could have during the current COVID‐19 pandemic. Howe...

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Detalles Bibliográficos
Autores principales: Castagna, Alberto, Ruotolo, Giovanni, Manzo, Ciro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954841/
https://www.ncbi.nlm.nih.gov/pubmed/33738381
http://dx.doi.org/10.1002/agm2.12140
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author Castagna, Alberto
Ruotolo, Giovanni
Manzo, Ciro
author_facet Castagna, Alberto
Ruotolo, Giovanni
Manzo, Ciro
author_sort Castagna, Alberto
collection PubMed
description Hydroxychloroquine (HCQ) is an antimalarial drug also known to have anti‐inflammatory and antiviral effects. The antiviral action of HCQ has been a point of interest for many researchers because of its mechanism of action and the potential use it could have during the current COVID‐19 pandemic. However, HCQ can cause QT interval prolongation. The current therapies used in COVID‐19 are changing as the pandemic develops. The aim of this article is to promote a validated risk score for QT prolongation in multidimensional assessment of COVID‐19 patients, especially in elderly and polypathological patients.
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spelling pubmed-79548412021-03-17 Progress in the risk assessment of hydroxychloroquine in frail elderly people Castagna, Alberto Ruotolo, Giovanni Manzo, Ciro Aging Med (Milton) Review Article Hydroxychloroquine (HCQ) is an antimalarial drug also known to have anti‐inflammatory and antiviral effects. The antiviral action of HCQ has been a point of interest for many researchers because of its mechanism of action and the potential use it could have during the current COVID‐19 pandemic. However, HCQ can cause QT interval prolongation. The current therapies used in COVID‐19 are changing as the pandemic develops. The aim of this article is to promote a validated risk score for QT prolongation in multidimensional assessment of COVID‐19 patients, especially in elderly and polypathological patients. John Wiley and Sons Inc. 2020-12-25 /pmc/articles/PMC7954841/ /pubmed/33738381 http://dx.doi.org/10.1002/agm2.12140 Text en © 2020 The Authors. Aging Medicine published by Beijing Hospital and John Wiley & Sons Australia, Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Castagna, Alberto
Ruotolo, Giovanni
Manzo, Ciro
Progress in the risk assessment of hydroxychloroquine in frail elderly people
title Progress in the risk assessment of hydroxychloroquine in frail elderly people
title_full Progress in the risk assessment of hydroxychloroquine in frail elderly people
title_fullStr Progress in the risk assessment of hydroxychloroquine in frail elderly people
title_full_unstemmed Progress in the risk assessment of hydroxychloroquine in frail elderly people
title_short Progress in the risk assessment of hydroxychloroquine in frail elderly people
title_sort progress in the risk assessment of hydroxychloroquine in frail elderly people
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954841/
https://www.ncbi.nlm.nih.gov/pubmed/33738381
http://dx.doi.org/10.1002/agm2.12140
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