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Cullin-5 neddylation-mediated NOXA degradation is enhanced by PRDX1 oligomers in colorectal cancer

NOXA, a BH3-only proapoptotic protein involved in regulating cell death decisions, is highly expressed but short-lived in colorectal cancer (CRC). Neddylated cullin-5 (CUL5)-mediated ubiquitination and degradation of NOXA is crucial to prevent its overaccumulation and maintain an appropriate action...

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Detalles Bibliográficos
Autores principales:	Xu, Shoufang, Ma, Yilei, Tong, Qingchao, Yang, Jun, Liu, Jia, Wang, Yanzhong, Li, Guoli, Zeng, Jin, Fang, Sining, Li, Fengying, Xie, Xinyou, Zhang, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954848/ https://www.ncbi.nlm.nih.gov/pubmed/33712558 http://dx.doi.org/10.1038/s41419-021-03557-3

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