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4CMenB Immunization Induces Serum Bactericidal Antibodies Against Non-Serogroup B Meningococcal Strains in Adolescents
INTRODUCTION: Invasive meningococcal disease (IMD) is an important public health concern. In developed countries, most IMD is caused by meningococcal serogroup B (MenB) and two protein-based MenB vaccines are currently available: the four-component vaccine 4CMenB (Bexsero, GSK) and the bivalent vacc...
Autores principales: | , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Healthcare
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954916/ https://www.ncbi.nlm.nih.gov/pubmed/33185849 http://dx.doi.org/10.1007/s40121-020-00370-x |
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author | Biolchi, Alessia Tomei, Sara Brunelli, Brunella Giuliani, Maria Bambini, Stefania Borrow, Ray Claus, Heike Gorla, Maria Cecilia O. Hong, Eva Lemos, Ana Paula S. Lucidarme, Jay Taha, Muhamed-Kheir Vogel, Ulrich Budroni, Sonia Giuliani, Marzia M. Rappuoli, Rino Boucher, Philip Pizza, Mariagrazia |
author_facet | Biolchi, Alessia Tomei, Sara Brunelli, Brunella Giuliani, Maria Bambini, Stefania Borrow, Ray Claus, Heike Gorla, Maria Cecilia O. Hong, Eva Lemos, Ana Paula S. Lucidarme, Jay Taha, Muhamed-Kheir Vogel, Ulrich Budroni, Sonia Giuliani, Marzia M. Rappuoli, Rino Boucher, Philip Pizza, Mariagrazia |
author_sort | Biolchi, Alessia |
collection | PubMed |
description | INTRODUCTION: Invasive meningococcal disease (IMD) is an important public health concern. In developed countries, most IMD is caused by meningococcal serogroup B (MenB) and two protein-based MenB vaccines are currently available: the four-component vaccine 4CMenB (Bexsero, GSK) and the bivalent vaccine MenB-FHbp (Trumenba, Pfizer). Genes encoding the 4CMenB vaccine antigens are also present in strains belonging to other meningococcal serogroups. METHODS: To evaluate the potential of 4CMenB vaccination to protect adolescents against non-MenB IMD, we tested the bactericidal activity of sera from immunized adolescents on 147 (127 European and 20 Brazilian) non-MenB IMD isolates, with a serum bactericidal antibody assay using human complement (hSBA). Serum pools were prepared using samples from randomly selected participants in various clinical trials, pre- and post-vaccination: 12 adolescents who received two doses of 4CMenB 2 months apart, and 10 adolescents who received a single dose of a MenACWY conjugate vaccine (as positive control). RESULTS: 4CMenB pre-immune sera killed 7.5% of the 147 non-MenB isolates at hSBA titers ≥ 1:4. In total, 91 (61.9%) tested isolates were killed by post-dose 2 pooled sera at hSBA titers ≥ 1:4, corresponding to 44/80 (55.0%) MenC, 26/35 (74.3%) MenW, and 21/32 (65.6%) MenY isolates killed. CONCLUSION: 4CMenB vaccination in adolescents induces bactericidal killing of non-MenB isolates, suggesting that mass vaccination could impact IMD due to serogroups other than MenB. |
format | Online Article Text |
id | pubmed-7954916 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer Healthcare |
record_format | MEDLINE/PubMed |
spelling | pubmed-79549162021-03-28 4CMenB Immunization Induces Serum Bactericidal Antibodies Against Non-Serogroup B Meningococcal Strains in Adolescents Biolchi, Alessia Tomei, Sara Brunelli, Brunella Giuliani, Maria Bambini, Stefania Borrow, Ray Claus, Heike Gorla, Maria Cecilia O. Hong, Eva Lemos, Ana Paula S. Lucidarme, Jay Taha, Muhamed-Kheir Vogel, Ulrich Budroni, Sonia Giuliani, Marzia M. Rappuoli, Rino Boucher, Philip Pizza, Mariagrazia Infect Dis Ther Original Research INTRODUCTION: Invasive meningococcal disease (IMD) is an important public health concern. In developed countries, most IMD is caused by meningococcal serogroup B (MenB) and two protein-based MenB vaccines are currently available: the four-component vaccine 4CMenB (Bexsero, GSK) and the bivalent vaccine MenB-FHbp (Trumenba, Pfizer). Genes encoding the 4CMenB vaccine antigens are also present in strains belonging to other meningococcal serogroups. METHODS: To evaluate the potential of 4CMenB vaccination to protect adolescents against non-MenB IMD, we tested the bactericidal activity of sera from immunized adolescents on 147 (127 European and 20 Brazilian) non-MenB IMD isolates, with a serum bactericidal antibody assay using human complement (hSBA). Serum pools were prepared using samples from randomly selected participants in various clinical trials, pre- and post-vaccination: 12 adolescents who received two doses of 4CMenB 2 months apart, and 10 adolescents who received a single dose of a MenACWY conjugate vaccine (as positive control). RESULTS: 4CMenB pre-immune sera killed 7.5% of the 147 non-MenB isolates at hSBA titers ≥ 1:4. In total, 91 (61.9%) tested isolates were killed by post-dose 2 pooled sera at hSBA titers ≥ 1:4, corresponding to 44/80 (55.0%) MenC, 26/35 (74.3%) MenW, and 21/32 (65.6%) MenY isolates killed. CONCLUSION: 4CMenB vaccination in adolescents induces bactericidal killing of non-MenB isolates, suggesting that mass vaccination could impact IMD due to serogroups other than MenB. Springer Healthcare 2020-11-13 2021-03 /pmc/articles/PMC7954916/ /pubmed/33185849 http://dx.doi.org/10.1007/s40121-020-00370-x Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/. |
spellingShingle | Original Research Biolchi, Alessia Tomei, Sara Brunelli, Brunella Giuliani, Maria Bambini, Stefania Borrow, Ray Claus, Heike Gorla, Maria Cecilia O. Hong, Eva Lemos, Ana Paula S. Lucidarme, Jay Taha, Muhamed-Kheir Vogel, Ulrich Budroni, Sonia Giuliani, Marzia M. Rappuoli, Rino Boucher, Philip Pizza, Mariagrazia 4CMenB Immunization Induces Serum Bactericidal Antibodies Against Non-Serogroup B Meningococcal Strains in Adolescents |
title | 4CMenB Immunization Induces Serum Bactericidal Antibodies Against Non-Serogroup B Meningococcal Strains in Adolescents |
title_full | 4CMenB Immunization Induces Serum Bactericidal Antibodies Against Non-Serogroup B Meningococcal Strains in Adolescents |
title_fullStr | 4CMenB Immunization Induces Serum Bactericidal Antibodies Against Non-Serogroup B Meningococcal Strains in Adolescents |
title_full_unstemmed | 4CMenB Immunization Induces Serum Bactericidal Antibodies Against Non-Serogroup B Meningococcal Strains in Adolescents |
title_short | 4CMenB Immunization Induces Serum Bactericidal Antibodies Against Non-Serogroup B Meningococcal Strains in Adolescents |
title_sort | 4cmenb immunization induces serum bactericidal antibodies against non-serogroup b meningococcal strains in adolescents |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954916/ https://www.ncbi.nlm.nih.gov/pubmed/33185849 http://dx.doi.org/10.1007/s40121-020-00370-x |
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