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Prospective Observational Study to Determine Kinetics of Procalcitonin in Hospitalized Children Receiving Antibiotic Therapy for Non-Critical Acute Bacterial Infections

INTRODUCTION: The kinetics of procalcitonin in pediatric patients with non-critical acute bacterial infections receiving appropriate antibiotic therapy are not well described. METHODS: We performed a single-center, prospective observational pilot study of children admitted to a tertiary care childre...

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Autores principales: Katz, Sophie E., Crook, Jennifer, McHenry, Rendie, Szeles, Andras, Halasa, Natasha, Banerjee, Ritu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954993/
https://www.ncbi.nlm.nih.gov/pubmed/33064296
http://dx.doi.org/10.1007/s40121-020-00358-7
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author Katz, Sophie E.
Crook, Jennifer
McHenry, Rendie
Szeles, Andras
Halasa, Natasha
Banerjee, Ritu
author_facet Katz, Sophie E.
Crook, Jennifer
McHenry, Rendie
Szeles, Andras
Halasa, Natasha
Banerjee, Ritu
author_sort Katz, Sophie E.
collection PubMed
description INTRODUCTION: The kinetics of procalcitonin in pediatric patients with non-critical acute bacterial infections receiving appropriate antibiotic therapy are not well described. METHODS: We performed a single-center, prospective observational pilot study of children admitted to a tertiary care children’s hospital who were receiving antibiotics for treatment of a non-critical acute bacterial infection, and we prospectively measured serial procalcitonin levels daily for 4 days during hospitalization. RESULTS: Among the 46 children with baseline procalcitonin levels enrolled in the study, procalcitonin kinetics followed a half-life of approximately 24 h in most patients. Procalcitonin declined faster than C-reactive protein over the first 48 h of appropriate antibiotic treatment. There was variation in biomarker levels among participants with the same infection type, especially in participants with bacteremia, musculoskeletal infection and skin/soft tissue infection. CONCLUSION: Utility of procalcitonin as a biomarker to follow every 24–48 h in non-critically ill children receiving antibiotic therapy for bacterial infections as an objective measure of clinical improvement is promising.
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spelling pubmed-79549932021-03-28 Prospective Observational Study to Determine Kinetics of Procalcitonin in Hospitalized Children Receiving Antibiotic Therapy for Non-Critical Acute Bacterial Infections Katz, Sophie E. Crook, Jennifer McHenry, Rendie Szeles, Andras Halasa, Natasha Banerjee, Ritu Infect Dis Ther Brief Report INTRODUCTION: The kinetics of procalcitonin in pediatric patients with non-critical acute bacterial infections receiving appropriate antibiotic therapy are not well described. METHODS: We performed a single-center, prospective observational pilot study of children admitted to a tertiary care children’s hospital who were receiving antibiotics for treatment of a non-critical acute bacterial infection, and we prospectively measured serial procalcitonin levels daily for 4 days during hospitalization. RESULTS: Among the 46 children with baseline procalcitonin levels enrolled in the study, procalcitonin kinetics followed a half-life of approximately 24 h in most patients. Procalcitonin declined faster than C-reactive protein over the first 48 h of appropriate antibiotic treatment. There was variation in biomarker levels among participants with the same infection type, especially in participants with bacteremia, musculoskeletal infection and skin/soft tissue infection. CONCLUSION: Utility of procalcitonin as a biomarker to follow every 24–48 h in non-critically ill children receiving antibiotic therapy for bacterial infections as an objective measure of clinical improvement is promising. Springer Healthcare 2020-10-16 2021-03 /pmc/articles/PMC7954993/ /pubmed/33064296 http://dx.doi.org/10.1007/s40121-020-00358-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Brief Report
Katz, Sophie E.
Crook, Jennifer
McHenry, Rendie
Szeles, Andras
Halasa, Natasha
Banerjee, Ritu
Prospective Observational Study to Determine Kinetics of Procalcitonin in Hospitalized Children Receiving Antibiotic Therapy for Non-Critical Acute Bacterial Infections
title Prospective Observational Study to Determine Kinetics of Procalcitonin in Hospitalized Children Receiving Antibiotic Therapy for Non-Critical Acute Bacterial Infections
title_full Prospective Observational Study to Determine Kinetics of Procalcitonin in Hospitalized Children Receiving Antibiotic Therapy for Non-Critical Acute Bacterial Infections
title_fullStr Prospective Observational Study to Determine Kinetics of Procalcitonin in Hospitalized Children Receiving Antibiotic Therapy for Non-Critical Acute Bacterial Infections
title_full_unstemmed Prospective Observational Study to Determine Kinetics of Procalcitonin in Hospitalized Children Receiving Antibiotic Therapy for Non-Critical Acute Bacterial Infections
title_short Prospective Observational Study to Determine Kinetics of Procalcitonin in Hospitalized Children Receiving Antibiotic Therapy for Non-Critical Acute Bacterial Infections
title_sort prospective observational study to determine kinetics of procalcitonin in hospitalized children receiving antibiotic therapy for non-critical acute bacterial infections
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7954993/
https://www.ncbi.nlm.nih.gov/pubmed/33064296
http://dx.doi.org/10.1007/s40121-020-00358-7
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