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Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices

INTRODUCTION: The objective of this study was to describe two challenging cases of intravascular foreign body infections caused by multidrug-resistant Gram-negative pathogens requiring complex antimicrobial regimens including cefiderocol and successfully treated without implant removal. METHODS: Cli...

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Autores principales: Bodro, Marta, Hernández-Meneses, Marta, Ambrosioni, Juan, Linares, Laura, Moreno, Asunción, Sandoval, Elena, Olivas, Pol, Hernández-Tejero, María, Miró, José M., Marco, Francesc, Soriano, Alex
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Healthcare 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955010/
https://www.ncbi.nlm.nih.gov/pubmed/33417231
http://dx.doi.org/10.1007/s40121-020-00385-4
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author Bodro, Marta
Hernández-Meneses, Marta
Ambrosioni, Juan
Linares, Laura
Moreno, Asunción
Sandoval, Elena
Olivas, Pol
Hernández-Tejero, María
Miró, José M.
Marco, Francesc
Soriano, Alex
author_facet Bodro, Marta
Hernández-Meneses, Marta
Ambrosioni, Juan
Linares, Laura
Moreno, Asunción
Sandoval, Elena
Olivas, Pol
Hernández-Tejero, María
Miró, José M.
Marco, Francesc
Soriano, Alex
author_sort Bodro, Marta
collection PubMed
description INTRODUCTION: The objective of this study was to describe two challenging cases of intravascular foreign body infections caused by multidrug-resistant Gram-negative pathogens requiring complex antimicrobial regimens including cefiderocol and successfully treated without implant removal. METHODS: Clinical charts and microbiological reports of the clinical cases. RESULTS: Case 1 included a left ventricular assist device (HEARTMATE 3™Abbot(®)) infection due to Achromobacter xylosoxidans, while case 2 included a portal prosthesis infection due to Pseudomonas aeruginosa. As the pathogens were multidrug-resistant (MDR), both cases required antimicrobial regimens with cefiderocol; treatment was successful without implant removal. Importantly, case 1 presented a probable, drug-induced thrombocytopenia, a non-previously described side effect related to cefiderocol. CONCLUSION: Cefiderocol may be an additional, promising drug to the available arsenal, even for challenging foreign body infections caused by MDR Gram-negative pathogens.
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spelling pubmed-79550102021-03-28 Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices Bodro, Marta Hernández-Meneses, Marta Ambrosioni, Juan Linares, Laura Moreno, Asunción Sandoval, Elena Olivas, Pol Hernández-Tejero, María Miró, José M. Marco, Francesc Soriano, Alex Infect Dis Ther Case Series INTRODUCTION: The objective of this study was to describe two challenging cases of intravascular foreign body infections caused by multidrug-resistant Gram-negative pathogens requiring complex antimicrobial regimens including cefiderocol and successfully treated without implant removal. METHODS: Clinical charts and microbiological reports of the clinical cases. RESULTS: Case 1 included a left ventricular assist device (HEARTMATE 3™Abbot(®)) infection due to Achromobacter xylosoxidans, while case 2 included a portal prosthesis infection due to Pseudomonas aeruginosa. As the pathogens were multidrug-resistant (MDR), both cases required antimicrobial regimens with cefiderocol; treatment was successful without implant removal. Importantly, case 1 presented a probable, drug-induced thrombocytopenia, a non-previously described side effect related to cefiderocol. CONCLUSION: Cefiderocol may be an additional, promising drug to the available arsenal, even for challenging foreign body infections caused by MDR Gram-negative pathogens. Springer Healthcare 2021-01-08 2021-03 /pmc/articles/PMC7955010/ /pubmed/33417231 http://dx.doi.org/10.1007/s40121-020-00385-4 Text en © The Author(s) 2021 Open Access This article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle Case Series
Bodro, Marta
Hernández-Meneses, Marta
Ambrosioni, Juan
Linares, Laura
Moreno, Asunción
Sandoval, Elena
Olivas, Pol
Hernández-Tejero, María
Miró, José M.
Marco, Francesc
Soriano, Alex
Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices
title Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices
title_full Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices
title_fullStr Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices
title_full_unstemmed Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices
title_short Salvage Treatment with Cefiderocol Regimens in Two Intravascular Foreign Body Infections by MDR Gram-Negative Pathogens, Involving Non-Removable Devices
title_sort salvage treatment with cefiderocol regimens in two intravascular foreign body infections by mdr gram-negative pathogens, involving non-removable devices
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955010/
https://www.ncbi.nlm.nih.gov/pubmed/33417231
http://dx.doi.org/10.1007/s40121-020-00385-4
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