Optimal Management of Acute Severe Ulcerative Colitis (ASUC): Challenges and Solutions

Acute severe colitis is a severe complication of ulcerative colitis, affecting approximately 20% of patients. For physicians, it remains a challenging condition to treat. Current treatment algorithms have diminished the mortality associated with acute severe ulcerative colitis (ASUC), but colectomy...

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Detalles Bibliográficos
Autores principales: Holvoet, Tom, Lobaton, Triana, Hindryckx, Pieter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955027/
https://www.ncbi.nlm.nih.gov/pubmed/33727846
http://dx.doi.org/10.2147/CEG.S197719
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author Holvoet, Tom
Lobaton, Triana
Hindryckx, Pieter
author_facet Holvoet, Tom
Lobaton, Triana
Hindryckx, Pieter
author_sort Holvoet, Tom
collection PubMed
description Acute severe colitis is a severe complication of ulcerative colitis, affecting approximately 20% of patients. For physicians, it remains a challenging condition to treat. Current treatment algorithms have diminished the mortality associated with acute severe ulcerative colitis (ASUC), but colectomy rates remain high (approximately 30%) despite advances in therapy. Colectomy in ASUC is particularly associated with important postoperative complications and morbidity. In this review, reasons for the inability to improve care and avoid evolution to colectomy for ASUC are explored and solutions that might lead to a better management of the disease are investigated.
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spelling pubmed-79550272021-03-15 Optimal Management of Acute Severe Ulcerative Colitis (ASUC): Challenges and Solutions Holvoet, Tom Lobaton, Triana Hindryckx, Pieter Clin Exp Gastroenterol Review Acute severe colitis is a severe complication of ulcerative colitis, affecting approximately 20% of patients. For physicians, it remains a challenging condition to treat. Current treatment algorithms have diminished the mortality associated with acute severe ulcerative colitis (ASUC), but colectomy rates remain high (approximately 30%) despite advances in therapy. Colectomy in ASUC is particularly associated with important postoperative complications and morbidity. In this review, reasons for the inability to improve care and avoid evolution to colectomy for ASUC are explored and solutions that might lead to a better management of the disease are investigated. Dove 2021-03-08 /pmc/articles/PMC7955027/ /pubmed/33727846 http://dx.doi.org/10.2147/CEG.S197719 Text en © 2021 Holvoet et al. http://creativecommons.org/licenses/by-nc/3.0/ This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Holvoet, Tom
Lobaton, Triana
Hindryckx, Pieter
Optimal Management of Acute Severe Ulcerative Colitis (ASUC): Challenges and Solutions
title Optimal Management of Acute Severe Ulcerative Colitis (ASUC): Challenges and Solutions
title_full Optimal Management of Acute Severe Ulcerative Colitis (ASUC): Challenges and Solutions
title_fullStr Optimal Management of Acute Severe Ulcerative Colitis (ASUC): Challenges and Solutions
title_full_unstemmed Optimal Management of Acute Severe Ulcerative Colitis (ASUC): Challenges and Solutions
title_short Optimal Management of Acute Severe Ulcerative Colitis (ASUC): Challenges and Solutions
title_sort optimal management of acute severe ulcerative colitis (asuc): challenges and solutions
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955027/
https://www.ncbi.nlm.nih.gov/pubmed/33727846
http://dx.doi.org/10.2147/CEG.S197719
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