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Creb5 establishes the competence for Prg4 expression in articular cartilage

A hallmark of cells comprising the superficial zone of articular cartilage is their expression of lubricin, encoded by the Prg4 gene, that lubricates the joint and protects against the development of arthritis. Here, we identify Creb5 as a transcription factor that is specifically expressed in super...

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Detalles Bibliográficos
Autores principales: Zhang, Cheng-Hai, Gao, Yao, Jadhav, Unmesh, Hung, Han-Hwa, Holton, Kristina M., Grodzinsky, Alan J., Shivdasani, Ramesh A., Lassar, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955038/
https://www.ncbi.nlm.nih.gov/pubmed/33712729
http://dx.doi.org/10.1038/s42003-021-01857-0