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Cryo-EM structure of the Rous sarcoma virus octameric cleaved synaptic complex intasome

Despite conserved catalytic integration mechanisms, retroviral intasomes composed of integrase (IN) and viral DNA possess diverse structures with variable numbers of IN subunits. To investigate intasome assembly mechanisms, we employed the Rous sarcoma virus (RSV) IN dimer that assembles a precursor...

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Detalles Bibliográficos
Autores principales:	Pandey, Krishan K., Bera, Sibes, Shi, Ke, Rau, Michael J., Oleru, Amarachi V., Fitzpatrick, James A. J., Engelman, Alan N., Aihara, Hideki, Grandgenett, Duane P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955051/ https://www.ncbi.nlm.nih.gov/pubmed/33712691 http://dx.doi.org/10.1038/s42003-021-01855-2

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