Antibody design using LSTM based deep generative model from phage display library for affinity maturation

Molecular evolution is an important step in the development of therapeutic antibodies. However, the current method of affinity maturation is overly costly and labor-intensive because of the repetitive mutation experiments needed to adequately explore sequence space. Here, we employed a long short te...

Descripción completa

Detalles Bibliográficos
Autores principales: Saka, Koichiro, Kakuzaki, Taro, Metsugi, Shoichi, Kashiwagi, Daiki, Yoshida, Kenji, Wada, Manabu, Tsunoda, Hiroyuki, Teramoto, Reiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955064/
https://www.ncbi.nlm.nih.gov/pubmed/33712669
http://dx.doi.org/10.1038/s41598-021-85274-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955064/
https://www.ncbi.nlm.nih.gov/pubmed/33712669
http://dx.doi.org/10.1038/s41598-021-85274-7

Ejemplares similares