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Antibody design using LSTM based deep generative model from phage display library for affinity maturation
Molecular evolution is an important step in the development of therapeutic antibodies. However, the current method of affinity maturation is overly costly and labor-intensive because of the repetitive mutation experiments needed to adequately explore sequence space. Here, we employed a long short te...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955064/ https://www.ncbi.nlm.nih.gov/pubmed/33712669 http://dx.doi.org/10.1038/s41598-021-85274-7 |