Single-cell transcriptional changes associated with drug tolerance and response to combination therapies in cancer

Tyrosine kinase inhibitors were found to be clinically effective for treatment of patients with certain subsets of cancers carrying somatic mutations in receptor tyrosine kinases. However, the duration of clinical response is often limited, and patients ultimately develop drug resistance. Here, we u...

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Detalles Bibliográficos
Autores principales: Aissa, Alexandre F., Islam, Abul B. M. M. K., Ariss, Majd M., Go, Cammille C., Rader, Alexandra E., Conrardy, Ryan D., Gajda, Alexa M., Rubio-Perez, Carlota, Valyi-Nagy, Klara, Pasquinelli, Mary, Feldman, Lawrence E., Green, Stefan J., Lopez-Bigas, Nuria, Frolov, Maxim V., Benevolenskaya, Elizaveta V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955121/
https://www.ncbi.nlm.nih.gov/pubmed/33712615
http://dx.doi.org/10.1038/s41467-021-21884-z

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