Cargando…

Cardiometabolic traits mediating the effect of education on osteoarthritis risk: a Mendelian randomization study

OBJECTIVE: To investigate which cardiometabolic factors underlie clustering of osteoarthritis (OA) with cardiovascular disease, and the extent to which these mediate an effect of education. DESIGN: Genome-wide association study (GWAS) of OA was performed in UK Biobank (60,800 cases and 328,251 contr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gill, D., Karhunen, V., Malik, R., Dichgans, M., Sofat, N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	W.B. Saunders For The Osteoarthritis Research Society 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955282/ https://www.ncbi.nlm.nih.gov/pubmed/33422704 http://dx.doi.org/10.1016/j.joca.2020.12.015

Ejemplares similares

Genetically Predicted Midlife Blood Pressure and Coronary Artery Disease Risk: Mendelian Randomization Analysis
por: Gill, Dipender, et al.
Publicado: (2020)

The Role of Adiposity in Cardiometabolic Traits: A Mendelian Randomization Analysis
por: Fall, Tove, et al.
Publicado: (2013)

Cardiometabolic Traits, Sepsis, and Severe COVID-19: A Mendelian Randomization Investigation
por: Ponsford, Mark J., et al.
Publicado: (2020)

Independent Associations of Education, Intelligence, and Cognition With Hypertension and the Mediating Effects of Cardiometabolic Risk Factors: A Mendelian Randomization Study
por: Wang, Yiying, et al.
Publicado: (2022)

Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study
por: Georgakis, Marios K., et al.
Publicado: (2021)

The interplay between inflammatory cytokines and cardiometabolic disease: bi-directional mendelian randomisation study
por: Karhunen, Ville, et al.
Publicado: (2023)

Metabolic Traits and Stroke Risk in Individuals of African Ancestry: Mendelian Randomization Analysis
por: Fatumo, Segun, et al.
Publicado: (2021)

Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis
por: Harshfield, Eric L., et al.
Publicado: (2021)

Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes: A Mendelian Randomization Study
por: Georgakis, Marios K., et al.
Publicado: (2020)

Cardiac Risk Factors for Stroke: A Comprehensive Mendelian Randomization Study
por: Frerich, Simon, et al.
Publicado: (2021)

Modifiable Risk Factors for Intracranial Aneurysm and Aneurysmal Subarachnoid Hemorrhage: A Mendelian Randomization Study
por: Karhunen, Ville, et al.
Publicado: (2021)

Relationship Between Blood Pressure and Incident Cardiovascular Disease: Linear and Nonlinear Mendelian Randomization Analyses
por: Malik, Rainer, et al.
Publicado: (2021)

Blood copper and risk of cardiometabolic diseases: a Mendelian randomization study
por: Jäger, Susanne, et al.
Publicado: (2021)

A Bidirectional Mendelian Randomization Study of Sarcopenia-Related Traits and Knee Osteoarthritis
por: Zhang, Longyao, et al.
Publicado: (2023)

Influence of puberty timing on adiposity and cardiometabolic traits: A Mendelian randomisation study
por: Bell, Joshua A., et al.
Publicado: (2018)

Inhibition of interleukin 6 signalling and renal function: A Mendelian randomization study
por: Ryan, David K., et al.
Publicado: (2021)

Genetically Proxied Inhibition of Coagulation Factors and Risk of Cardiovascular Disease: A Mendelian Randomization Study
por: Yuan, Shuai, et al.
Publicado: (2021)

Schizophrenia and cardiometabolic abnormalities: A Mendelian randomization study
por: Saadullah Khani, Noushin, et al.
Publicado: (2023)

Causal associations of sarcopenia‐related traits with cardiometabolic disease and Alzheimer's disease and the mediating role of insulin resistance: A Mendelian randomization study
por: Ye, Chaojie, et al.
Publicado: (2023)

Cardiometabolic risks of SARS-CoV-2 hospitalization using Mendelian Randomization
por: Lorincz-Comi, Noah, et al.
Publicado: (2021)

Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study
por: Lankester, Joanna, et al.
Publicado: (2021)

Lipid traits and type 2 diabetes risk in African ancestry individuals: A Mendelian Randomization study
por: Soremekun, Opeyemi, et al.
Publicado: (2022)

Cardiometabolic risk factors for COVID-19 susceptibility and severity: A Mendelian randomization analysis
por: Leong, Aaron, et al.
Publicado: (2021)

Circulating biomarkers of immunity and inflammation, risk of Alzheimer’s disease, and hippocampal volume: a Mendelian randomization study
por: Fani, Lana, et al.
Publicado: (2021)

Risk factors mediating the effect of body mass index and waist-to-hip ratio on cardiovascular outcomes: Mendelian randomization analysis
por: Gill, Dipender, et al.
Publicado: (2021)

Genetic evidence implicating natriuretic peptide receptor-3 in cardiovascular disease risk: a Mendelian randomization study
por: Cronjé, Héléne T., et al.
Publicado: (2023)

Mendelian randomization study of maternal influences on birthweight and future cardiometabolic risk in the HUNT cohort
por: Moen, Gunn-Helen, et al.
Publicado: (2020)

SGLT2 Inhibition, Choline Metabolites, and Cardiometabolic Diseases: A Mediation Mendelian Randomization Study
por: Xu, Min, et al.
Publicado: (2022)

Impact of the gut microbiota and associated metabolites on cardiometabolic traits, chronic diseases and human longevity: a Mendelian randomization study
por: Gagnon, Eloi, et al.
Publicado: (2023)

Cardiometabolic Polygenic Risk Scores and Osteoarthritis Outcomes: A Mendelian Randomization Study Using Data From the Malmö Diet and Cancer Study and the UK Biobank
por: Hindy, George, et al.
Publicado: (2019)

Disentangling the effects of traits with shared clustered genetic predictors using multivariable Mendelian randomization
por: Batool, Fatima, et al.
Publicado: (2022)

Appraising the Effects of Metabolic Traits on the Risk of Glaucoma: A Mendelian Randomization Study
por: Wang, Kai, et al.
Publicado: (2023)

Causal associations of remnant cholesterol with cardiometabolic diseases and risk factors: a mendelian randomization analysis
por: Guan, Baoyi, et al.
Publicado: (2023)

Mendelian randomization for studying the effects of perturbing drug targets
por: Gill, Dipender, et al.
Publicado: (2021)

The Causal Effect of Vitamin D Binding Protein (DBP) Levels on Calcemic and Cardiometabolic Diseases: A Mendelian Randomization Study
por: Leong, Aaron, et al.
Publicado: (2014)

Additive Effects of Genetic Interleukin‐6 Signaling Downregulation and Low‐Density Lipoprotein Cholesterol Lowering on Cardiovascular Disease: A 2×2 Factorial Mendelian Randomization Analysis
por: Georgakis, Marios K., et al.
Publicado: (2021)

Modifiable risk factors that mediate the effect of educational attainment on the risk of stroke: a network Mendelian randomization study
por: Wan, Bangbei, et al.
Publicado: (2023)

Association of 25-hydroxyvitamin D with cardiometabolic risk factors and metabolic syndrome: a mendelian randomization study
por: Chen, Chi, et al.
Publicado: (2019)

Genetically Higher Level of Mannose Has No Impact on Cardiometabolic Risk Factors: Insight from Mendelian Randomization
por: Mazidi, Mohsen, et al.
Publicado: (2021)

Lipid Metabolism Traits Mediate the Effect of Psoriasis on Myocardial Infarction Risk: A Two-Step Mendelian Randomization Study
por: Ding, Yang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_3ne66pjt3s86dhdfsv73hoq4vj