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Trends, Management, and Outcomes of Acute Myocardial Infarction Hospitalizations With In‐Hospital‐Onset Versus Out‐of‐Hospital Onset: The ARIC Study

BACKGROUND: Acute myocardial infarction (AMI) with in‐hospital onset (AMI‐IHO) has poor prognosis but is clinically underappreciated. Whether its occurrence has changed over time is uncertain. METHODS AND RESULTS: Since 1987, the ARIC (Atherosclerosis Risk in Communities) study has conducted adjudic...

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Autores principales: Caughey, Melissa C., Arora, Sameer, Qamar, Arman, Chunawala, Zainali, Gupta, Mohit D., Gupta, Puneet, Vaduganathan, Muthiah, Pandey, Ambarish, Dai, Xuming, Smith, Sidney C., Matsushita, Kunihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955301/
https://www.ncbi.nlm.nih.gov/pubmed/33399008
http://dx.doi.org/10.1161/JAHA.120.018414
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author Caughey, Melissa C.
Arora, Sameer
Qamar, Arman
Chunawala, Zainali
Gupta, Mohit D.
Gupta, Puneet
Vaduganathan, Muthiah
Pandey, Ambarish
Dai, Xuming
Smith, Sidney C.
Matsushita, Kunihiro
author_facet Caughey, Melissa C.
Arora, Sameer
Qamar, Arman
Chunawala, Zainali
Gupta, Mohit D.
Gupta, Puneet
Vaduganathan, Muthiah
Pandey, Ambarish
Dai, Xuming
Smith, Sidney C.
Matsushita, Kunihiro
author_sort Caughey, Melissa C.
collection PubMed
description BACKGROUND: Acute myocardial infarction (AMI) with in‐hospital onset (AMI‐IHO) has poor prognosis but is clinically underappreciated. Whether its occurrence has changed over time is uncertain. METHODS AND RESULTS: Since 1987, the ARIC (Atherosclerosis Risk in Communities) study has conducted adjudicated surveillance of AMI hospitalizations in 4 US communities. Our analysis was limited to patients aged 35 to 74 years with symptomatic AMI. Patients with symptoms initiating after hospital arrival were considered AMI‐IHO. A total of 26 678 weighted hospitalizations (14 276 unweighted hospitalizations) for symptomatic AMI were identified from 1995 to 2014, with 1137 (4%) classified as in‐hospital onset. The population incidence rate of AMI‐IHO increased in the 4 ARIC communities from 1995 through 2004 to 2005 through 2014 (12.7—16.9 events per 100 000 people; P for 20‐year trend <0.0001), as did the proportion of AMI hospitalizations with in‐hospital onset (3.7%–6.1%; P for 20‐year trend =0.03). The 10‐year proportions were stable for patients aged 35 to 64 years (3.0%–3.4%; P for 20‐year trend =0.3) but increased for patients aged ≥65 years (4.6%–7.8%; P for 20‐year trend =0.008; P for interaction by age group =0.04). AMI‐IHO had a more severe clinical course with lower use of AMI therapies or invasive strategies and higher in‐hospital (7% versus 3%), 28‐day (19% versus 5%), and 1‐year (29% versus 12%) mortality (P<0.0001 for all). CONCLUSIONS: In this population‐based community surveillance, AMI‐IHO increased from 2005 to 2014, particularly among older patients. Quality initiatives to improve recognition and management of AMI‐IHO should be especially focused on hospitalized patients aged >65.
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spelling pubmed-79553012021-03-17 Trends, Management, and Outcomes of Acute Myocardial Infarction Hospitalizations With In‐Hospital‐Onset Versus Out‐of‐Hospital Onset: The ARIC Study Caughey, Melissa C. Arora, Sameer Qamar, Arman Chunawala, Zainali Gupta, Mohit D. Gupta, Puneet Vaduganathan, Muthiah Pandey, Ambarish Dai, Xuming Smith, Sidney C. Matsushita, Kunihiro J Am Heart Assoc Original Research BACKGROUND: Acute myocardial infarction (AMI) with in‐hospital onset (AMI‐IHO) has poor prognosis but is clinically underappreciated. Whether its occurrence has changed over time is uncertain. METHODS AND RESULTS: Since 1987, the ARIC (Atherosclerosis Risk in Communities) study has conducted adjudicated surveillance of AMI hospitalizations in 4 US communities. Our analysis was limited to patients aged 35 to 74 years with symptomatic AMI. Patients with symptoms initiating after hospital arrival were considered AMI‐IHO. A total of 26 678 weighted hospitalizations (14 276 unweighted hospitalizations) for symptomatic AMI were identified from 1995 to 2014, with 1137 (4%) classified as in‐hospital onset. The population incidence rate of AMI‐IHO increased in the 4 ARIC communities from 1995 through 2004 to 2005 through 2014 (12.7—16.9 events per 100 000 people; P for 20‐year trend <0.0001), as did the proportion of AMI hospitalizations with in‐hospital onset (3.7%–6.1%; P for 20‐year trend =0.03). The 10‐year proportions were stable for patients aged 35 to 64 years (3.0%–3.4%; P for 20‐year trend =0.3) but increased for patients aged ≥65 years (4.6%–7.8%; P for 20‐year trend =0.008; P for interaction by age group =0.04). AMI‐IHO had a more severe clinical course with lower use of AMI therapies or invasive strategies and higher in‐hospital (7% versus 3%), 28‐day (19% versus 5%), and 1‐year (29% versus 12%) mortality (P<0.0001 for all). CONCLUSIONS: In this population‐based community surveillance, AMI‐IHO increased from 2005 to 2014, particularly among older patients. Quality initiatives to improve recognition and management of AMI‐IHO should be especially focused on hospitalized patients aged >65. John Wiley and Sons Inc. 2021-01-05 /pmc/articles/PMC7955301/ /pubmed/33399008 http://dx.doi.org/10.1161/JAHA.120.018414 Text en © 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Caughey, Melissa C.
Arora, Sameer
Qamar, Arman
Chunawala, Zainali
Gupta, Mohit D.
Gupta, Puneet
Vaduganathan, Muthiah
Pandey, Ambarish
Dai, Xuming
Smith, Sidney C.
Matsushita, Kunihiro
Trends, Management, and Outcomes of Acute Myocardial Infarction Hospitalizations With In‐Hospital‐Onset Versus Out‐of‐Hospital Onset: The ARIC Study
title Trends, Management, and Outcomes of Acute Myocardial Infarction Hospitalizations With In‐Hospital‐Onset Versus Out‐of‐Hospital Onset: The ARIC Study
title_full Trends, Management, and Outcomes of Acute Myocardial Infarction Hospitalizations With In‐Hospital‐Onset Versus Out‐of‐Hospital Onset: The ARIC Study
title_fullStr Trends, Management, and Outcomes of Acute Myocardial Infarction Hospitalizations With In‐Hospital‐Onset Versus Out‐of‐Hospital Onset: The ARIC Study
title_full_unstemmed Trends, Management, and Outcomes of Acute Myocardial Infarction Hospitalizations With In‐Hospital‐Onset Versus Out‐of‐Hospital Onset: The ARIC Study
title_short Trends, Management, and Outcomes of Acute Myocardial Infarction Hospitalizations With In‐Hospital‐Onset Versus Out‐of‐Hospital Onset: The ARIC Study
title_sort trends, management, and outcomes of acute myocardial infarction hospitalizations with in‐hospital‐onset versus out‐of‐hospital onset: the aric study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955301/
https://www.ncbi.nlm.nih.gov/pubmed/33399008
http://dx.doi.org/10.1161/JAHA.120.018414
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