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Coronary Artery Calcium and Cognitive Function in Dutch Adults: Cross‐Sectional Results of the Population‐Based ImaLife Study

BACKGROUND: The aim of this study was to investigate whether increased severity of coronary artery calcium (CAC), an imaging biomarker of subclinical coronary atherosclerosis, is associated with worse cognitive function independent of cardiovascular risk factors in a large population‐based Dutch coh...

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Autores principales: Xia, Congying, Vonder, Marleen, Sidorenkov, Grigory, Ma, Runlei, Oudkerk, Matthijs, van der Harst, Pim, De Deyn, Peter Paul, Vliegenthart, Rozemarijn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955332/
https://www.ncbi.nlm.nih.gov/pubmed/33525927
http://dx.doi.org/10.1161/JAHA.120.018172
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author Xia, Congying
Vonder, Marleen
Sidorenkov, Grigory
Ma, Runlei
Oudkerk, Matthijs
van der Harst, Pim
De Deyn, Peter Paul
Vliegenthart, Rozemarijn
author_facet Xia, Congying
Vonder, Marleen
Sidorenkov, Grigory
Ma, Runlei
Oudkerk, Matthijs
van der Harst, Pim
De Deyn, Peter Paul
Vliegenthart, Rozemarijn
author_sort Xia, Congying
collection PubMed
description BACKGROUND: The aim of this study was to investigate whether increased severity of coronary artery calcium (CAC), an imaging biomarker of subclinical coronary atherosclerosis, is associated with worse cognitive function independent of cardiovascular risk factors in a large population‐based Dutch cohort with broad age range. METHODS AND RESULTS: A cross‐sectional analysis was performed in 4988 ImaLife participants (aged 45–91 years, 58.3% women) without history of cardiovascular disease. CAC scores were obtained using nonenhanced cardiac computed tomography scanning. The CogState Brief Battery was used to assess 4 cognitive domains: processing speed, attention, working memory, and visual learning based on detection task, identification task, 1‐back task, and 1‐card‐learning task, respectively. Differences in mean scores of each cognitive domain were compared among 4 CAC categories (0, 1–99, 100–399, ≥400) using analysis of covariates to adjust for classical cardiovascular risk factors. Age‐stratified analysis (45–54, 55–64, and ≥65 years) was performed to assess whether the association of CAC severity with cognitive function differed by age. Overall, higher CAC was associated with worse performance on 1‐back task after adjusting for classical cardiovascular risk factors, but CAC was not associated with the other cognitive tasks. Age‐stratified analyses revealed that the association of CAC severity with working memory persisted in participants aged 45 to 54 years, while in the elderly this association lost significance. CONCLUSIONS: In this Dutch population of ≥45 years, increased CAC severity was associated with worse performance of working memory, independent of classical cardiovascular risk factors. The inverse relationship of CAC score categories with working memory was strongest in participants aged 45 to 54 years.
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spelling pubmed-79553322021-03-17 Coronary Artery Calcium and Cognitive Function in Dutch Adults: Cross‐Sectional Results of the Population‐Based ImaLife Study Xia, Congying Vonder, Marleen Sidorenkov, Grigory Ma, Runlei Oudkerk, Matthijs van der Harst, Pim De Deyn, Peter Paul Vliegenthart, Rozemarijn J Am Heart Assoc Original Research BACKGROUND: The aim of this study was to investigate whether increased severity of coronary artery calcium (CAC), an imaging biomarker of subclinical coronary atherosclerosis, is associated with worse cognitive function independent of cardiovascular risk factors in a large population‐based Dutch cohort with broad age range. METHODS AND RESULTS: A cross‐sectional analysis was performed in 4988 ImaLife participants (aged 45–91 years, 58.3% women) without history of cardiovascular disease. CAC scores were obtained using nonenhanced cardiac computed tomography scanning. The CogState Brief Battery was used to assess 4 cognitive domains: processing speed, attention, working memory, and visual learning based on detection task, identification task, 1‐back task, and 1‐card‐learning task, respectively. Differences in mean scores of each cognitive domain were compared among 4 CAC categories (0, 1–99, 100–399, ≥400) using analysis of covariates to adjust for classical cardiovascular risk factors. Age‐stratified analysis (45–54, 55–64, and ≥65 years) was performed to assess whether the association of CAC severity with cognitive function differed by age. Overall, higher CAC was associated with worse performance on 1‐back task after adjusting for classical cardiovascular risk factors, but CAC was not associated with the other cognitive tasks. Age‐stratified analyses revealed that the association of CAC severity with working memory persisted in participants aged 45 to 54 years, while in the elderly this association lost significance. CONCLUSIONS: In this Dutch population of ≥45 years, increased CAC severity was associated with worse performance of working memory, independent of classical cardiovascular risk factors. The inverse relationship of CAC score categories with working memory was strongest in participants aged 45 to 54 years. John Wiley and Sons Inc. 2021-02-02 /pmc/articles/PMC7955332/ /pubmed/33525927 http://dx.doi.org/10.1161/JAHA.120.018172 Text en © 2021 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Research
Xia, Congying
Vonder, Marleen
Sidorenkov, Grigory
Ma, Runlei
Oudkerk, Matthijs
van der Harst, Pim
De Deyn, Peter Paul
Vliegenthart, Rozemarijn
Coronary Artery Calcium and Cognitive Function in Dutch Adults: Cross‐Sectional Results of the Population‐Based ImaLife Study
title Coronary Artery Calcium and Cognitive Function in Dutch Adults: Cross‐Sectional Results of the Population‐Based ImaLife Study
title_full Coronary Artery Calcium and Cognitive Function in Dutch Adults: Cross‐Sectional Results of the Population‐Based ImaLife Study
title_fullStr Coronary Artery Calcium and Cognitive Function in Dutch Adults: Cross‐Sectional Results of the Population‐Based ImaLife Study
title_full_unstemmed Coronary Artery Calcium and Cognitive Function in Dutch Adults: Cross‐Sectional Results of the Population‐Based ImaLife Study
title_short Coronary Artery Calcium and Cognitive Function in Dutch Adults: Cross‐Sectional Results of the Population‐Based ImaLife Study
title_sort coronary artery calcium and cognitive function in dutch adults: cross‐sectional results of the population‐based imalife study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955332/
https://www.ncbi.nlm.nih.gov/pubmed/33525927
http://dx.doi.org/10.1161/JAHA.120.018172
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