GIP Receptor Antagonist, SKL-14959 Indicated Alteration of the Lipids Metabolism to Catabolism by the Inhibition of Plasma LPL Activity, Resulting in the Suppression of Weight Gain on Diets-Induced Obesity Mice

INTRODUCTION: Glucose-dependent insulinotropic polypeptide (GIP) plays a crucial role in the regulation of lipid metabolism via lipoprotein lipase (LPL). GIP receptor antagonist, SKL-14959, suppressed the weight gain in the diet-induced obesity model. However, the mechanism is not unclear. Therefore...

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Detalles Bibliográficos
Autores principales: Nakamura, Takashi, Tanimoto, Hitomi, Okamoto, Masayuki, Takeuchi, Mitsuaki, Tsubamoto, Yoshiharu, Noda, Hitoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955685/
https://www.ncbi.nlm.nih.gov/pubmed/33727843
http://dx.doi.org/10.2147/DMSO.S297353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7955685/
https://www.ncbi.nlm.nih.gov/pubmed/33727843
http://dx.doi.org/10.2147/DMSO.S297353

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